{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:01:16Z","timestamp":1791198076953,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,5,13]],"date-time":"2013-05-13T00:00:00Z","timestamp":1368403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2013,7]]},"abstract":"Mast cells (MCs) are immune cells residing in tissues where pathogens are first encountered. It has been indicated that MCs might also be involved in setting the outcome of T<\/jats:styled-content>\u2010cell responses. However, little is known about the capacity of human MCs to express MHC<\/jats:styled-content> class II and\/or to capture and present antigens to CD<\/jats:styled-content>4+<\/jats:sup> T<\/jats:styled-content> cells. To study the T<\/jats:styled-content>\u2010cell stimulatory potential of human MCs, CD<\/jats:styled-content>34+<\/jats:sup> stem cell derived MCs were generated. These cells expressed HLA<\/jats:styled-content>\u2010DR<\/jats:styled-content> when stimulated with IFN<\/jats:styled-content>\u2010\u03b3, and, importantly, presented peptide and protein for activation of antigen\u2010specific CD<\/jats:styled-content>4+<\/jats:sup> T<\/jats:styled-content> cells. The interplay between MC and T<\/jats:styled-content> cell led to increased HLA<\/jats:styled-content>\u2010DR<\/jats:styled-content> expression on MCs. MCs were present in close proximity to T<\/jats:styled-content> cells in tonsil and expressed HLA<\/jats:styled-content>\u2010DR<\/jats:styled-content> and CD<\/jats:styled-content>80, indicating their ability to present antigens to CD<\/jats:styled-content>4+<\/jats:sup> T<\/jats:styled-content> cells in T<\/jats:styled-content>\u2010cell areas of human LNs. Our data show that MCs can present native antigens to human CD<\/jats:styled-content>4+<\/jats:sup> T<\/jats:styled-content> cells and that HLA<\/jats:styled-content>\u2010DR<\/jats:styled-content> expressing MCs are present in tonsil tissue, indicating that human MCs can directly activate T<\/jats:styled-content> cells and provide a rationale to study the potential of MCs to prime and\/or skew human T<\/jats:styled-content>\u2010cell responses.<\/jats:p>","DOI":"10.1002\/eji.201243058","type":"journal-article","created":{"date-parts":[[2013,4,18]],"date-time":"2013-04-18T10:46:52Z","timestamp":1366282012000},"page":"1758-1768","source":"Crossref","is-referenced-by-count":57,"title":["Communication between human mast cells and CD<\/scp>4+<\/sup>T<\/scp> cells through antigen\u2010dependent interactions"],"prefix":"10.1002","volume":"43","author":[{"given":"Jolien","family":"Suurmond","sequence":"first","affiliation":[{"name":"Department of Rheumatology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurgen","family":"van Heemst","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"van Heiningen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemarie L.","family":"Dorj\u00e9e","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco W.","family":"Schilham","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feddo B.","family":"van der Beek","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom W.J.","family":"Huizinga","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemie J.M.","family":"Schuerwegh","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Leiden University Medical Center Leiden The Netherlands"},{"name":"Department of Immunology\/Allergology\/Rheumatology University of Antwerp Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9 E.M.","family":"Toes","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1005"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI3704"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.7.4648"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"5663","DOI":"10.4049\/jimmunol.161.10.5663","article-title":"Regulation of T lymphocyte trafficking into lymph nodes during an immune response by the chemokines macrophage inflammatory protein (MIP)\u20101 alpha and MIP\u20101 beta","volume":"161","author":"Tedla N.","year":"1998","journal-title":"J. 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