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The functionally mature NKG2C<jats:sup>bright<\/jats:sup> NK\u2010cell subset expanding in HCMV<jats:sup>+<\/jats:sup> individuals displays inhibitory Ig\u2010like receptors (KIR and LILRB1) specific for self HLA class I, and low levels of NKp46 and NKp30 activating receptors. Such reconfiguration of the NK\u2010cell compartment appears particularly marked in immunocompromised patients and in children with symptomatic congenital infection, thus suggesting that its magnitude may be inversely related with the efficiency of the T\u2010cell\u2010mediated response. This effect of HCMV infection is reminiscent of the pattern of response of murine Ly49H<jats:sup>+<\/jats:sup> NK cells against murine CMV (MCMV), and it has been hypothesized that a cognate interaction of the CD94\/NKG2C receptor with HCMV\u2010infected cells may drive the expansion of the corresponding NK\u2010cell subset. Yet, the precise role of NKG2C<jats:sup>+<\/jats:sup> cells in the control of HCMV infection, the molecular mechanisms underlying the NK\u2010cell compartment redistribution, as well as its putative influence in the response to other pathogens and tumors remain open issues.<\/jats:p>","DOI":"10.1002\/eji.201243117","type":"journal-article","created":{"date-parts":[[2013,4,2]],"date-time":"2013-04-02T08:04:57Z","timestamp":1364889897000},"page":"1133-1141","source":"Crossref","is-referenced-by-count":122,"title":["Adaptive reconfiguration of the human NK\u2010cell compartment in response to cytomegalovirus: A different perspective of the host\u2010pathogen interaction"],"prefix":"10.1002","volume":"43","author":[{"given":"Aura","family":"Muntasell","sequence":"first","affiliation":[{"name":"IMIM (Hospital del Mar Medical Research Institute)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Vilches","sequence":"additional","affiliation":[{"name":"Immunogenetics\u2010HLA Hospital Universitario Puerta de Hierro  Majadahonda Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Angulo","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"L\u00f3pez\u2010Botet","sequence":"additional","affiliation":[{"name":"IMIM (Hospital del Mar Medical Research Institute)  Barcelona Spain"},{"name":"Immunology Unit Universitat Pompeu Fabra  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,25]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.23.021704.115526"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.19.1.197"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-09-077438"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.20.092501.134942"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2011.06.001"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-05-2058"},{"key":"e_1_2_12_8_1","first-page":"2629","volume-title":"Fields Virology","author":"Mocarski E. 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