{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T08:12:58Z","timestamp":1778832778131,"version":"3.51.4"},"reference-count":63,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,6,21]],"date-time":"2013-06-21T00:00:00Z","timestamp":1371772800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:p>This Viewpoint gives an overview of the inherited disorders that are characterized by defects of leukocyte trafficking. Three paradigmatic diseases have been selected: warts, hypogammaglobulinemia, infections, and myelokathexis; <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>iskott\u2013<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ldrich; and leukocyte adhesion deficiency syndromes. These conditions encompass defects in the steps that are required for leukocyte motility: from the response to chemokines, which is altered in warts, hypogammaglobulinemia, infections, and myelokathexis syndrome, to the impairment of leukocyte adhesion and migration found in leukocyte adhesion deficiency syndrome, and finally to abnormal actin filament formation, which is affected in leukocytes of <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>iskott\u2013<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ldrich syndrome patients.<\/jats:p>","DOI":"10.1002\/eji.201243155","type":"journal-article","created":{"date-parts":[[2013,4,30]],"date-time":"2013-04-30T09:35:36Z","timestamp":1367314536000},"page":"1436-1440","source":"Crossref","is-referenced-by-count":27,"title":["Defects of leukocyte migration in primary immunodeficiencies"],"prefix":"10.1002","volume":"43","author":[{"given":"Raffaele","family":"Badolato","sequence":"first","affiliation":[{"name":"Department of Pediatrics Institute of Molecular Medicine \u201cAngelo Nocivelli\u201d, University of Brescia, Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1149"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-10-3532"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-06-2289"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/156652411795677963"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-7-71"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-12-395608"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.45.28726"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.12.1133"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-05-025296"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-01-403378"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.05.058"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/31269"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0702229104"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2005.01.001"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-03-276972"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-07-368084"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2010.02.006"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1977.tb00654.x"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-03-272096"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-06-360586"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2724"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2007.08.005"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-008-8084-3"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1592"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e3282f30448"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20110896"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/85886"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-01-010249"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20062324"},{"key":"e_1_2_5_31_1","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.4049\/jimmunol.161.2.1026","volume":"161","author":"Badolato R.","year":"1998","journal-title":"J. Immunol."},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1998.00767.x"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.4.1142"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200112)31:12<3413::AID-IMMU3413>3.0.CO;2-P"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030033"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-06-096875"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.08.050"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-03-340265"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0804444"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201142231"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-04-426981"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.1.33"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-02-140715"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-09-379412"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-09-308197"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-07-2099"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198005223022102"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2011.10.004"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2011.06389.x"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.25.022106.141618"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.72.4.650"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-1191"},{"key":"e_1_2_5_53_1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/ng0501-73","volume":"28","author":"Lubke T.","year":"2001","journal-title":"Nat. Genet."},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0501-69"},{"key":"e_1_2_5_55_1","first-page":"307","volume":"4","author":"Etzioni A.","year":"1993","journal-title":"Immunodeficiency"},{"key":"e_1_2_5_56_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-09-2840"},{"key":"e_1_2_5_57_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-08-3334"},{"key":"e_1_2_5_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-009-9354-0"},{"key":"e_1_2_5_59_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-05-089227"},{"key":"e_1_2_5_60_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-10-182154"},{"key":"e_1_2_5_61_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-06-163162"},{"key":"e_1_2_5_62_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119697"},{"key":"e_1_2_5_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-008-9226-z"},{"key":"e_1_2_5_64_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201007141"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.201243155","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.201243155","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T00:27:32Z","timestamp":1696552052000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.201243155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":63,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1002\/eji.201243155"],"URL":"https:\/\/doi.org\/10.1002\/eji.201243155","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6]]}}}