{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T07:55:40Z","timestamp":1719302140654},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,1,16]],"date-time":"2013-01-16T00:00:00Z","timestamp":1358294400000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p>In the killer lymphocyte, the targeted delivery of perforin\u2010 and granzyme\u2010containing cytotoxic granules to the immunological synapse is crucial for the eradication of pathogen\u2010infected or transformed targets. This process is achieved through a tightly controlled and highly efficient granule exocytosis pathway. Mutations in the granule trafficking proteins <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>unc13\u20134, syntaxin 11, <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>unc18\u20132 or <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>ab27 leads to a fatal lapse of immune surveillance and can be manifested as haemophagocytic lymphohistiocytosis in humans. Elucidation of the role of these proteins in exocytic trafficking is pivotal for our understanding of their role in health and disease. In this issue of the <jats:italic>European Journal of Immunology<\/jats:italic>, D'Orlando et al. [Eur. J. Immunol. 2013. 43: 194\u2010208] make an important step in this direction, as they generate and characterise syntaxin 11 deficient mice. Herein, we discuss the role of syntaxin\u201011 in soluble <jats:styled-content style=\"fixed-case\">NSF<\/jats:styled-content> (N\u2010ethylmaleimide sensitive fusion) attachment protein receptors complex formation leading to cytotoxic lymphocyte degranulation and its importance in maintaining immune homeostasis.<\/jats:p>","DOI":"10.1002\/eji.201243221","type":"journal-article","created":{"date-parts":[[2013,1,16]],"date-time":"2013-01-16T11:40:09Z","timestamp":1358336409000},"page":"46-49","source":"Crossref","is-referenced-by-count":2,"title":["Deciphering the syntax of cytotoxic lymphocyte degranulation"],"prefix":"10.1002","volume":"43","author":[{"given":"Jamie A.","family":"Lopez","sequence":"first","affiliation":[{"name":"Cancer Immunology Program Peter MacCallum Cancer Centre  St. Andrews Place East Melbourne Australia"},{"name":"Sir Peter MacCallum Department of Oncology The University of Melbourne  Parkville Australia"},{"name":"Department of Pathology The University of Melbourne  Parkville Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilia","family":"Voskoboinik","sequence":"additional","affiliation":[{"name":"Cancer Immunology Program Peter MacCallum Cancer Centre  St. Andrews Place East Melbourne Australia"},{"name":"Sir Peter MacCallum Department of Oncology The University of Melbourne  Parkville Australia"},{"name":"Department of Genetics The University of Melbourne  Parkville Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,16]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201142343"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2803"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2012.04.001"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5446.1957"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00855-9"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi076"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.09.005"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI40732"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1980"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.047449"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI12274"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018444"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-05-430603"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.17.10317"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.8490"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2006.00474.x"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.12.016"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-02-074468"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102012\u201007\u2010440339"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102012\u201007\u2010441139"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0903815106"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-374355"},{"issue":"6","key":"e_1_2_4_24_1","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1242\/jcs.112.6.845","article-title":"Syntaxin 11 is associated with SNAP\u201023 on late endosomes and the trans\u2010Golgi network","volume":"112","author":"Valdez A. 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