{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:25:44Z","timestamp":1790871944717,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,6,21]],"date-time":"2013-06-21T00:00:00Z","timestamp":1371772800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:p>\n                    Protective immunity to\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    (\n                    <jats:italic>Mtb<\/jats:italic>\n                    ) remains poorly understood and the role of\n                    <jats:italic>Mtb<\/jats:italic>\n                    \u2010specific CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells is controversial. Here we performed a broad phenotypic and functional characterization of\n                    <jats:italic>Mtb<\/jats:italic>\n                    \u2010specific CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells in 326 subjects with latent\n                    <jats:italic>Mtb<\/jats:italic>\n                    infection (LTBI) or active TB disease (TB).\n                    <jats:italic>Mtb<\/jats:italic>\n                    \u2010specific CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells were detected in most (60%) TB patients and few (15%) LTBI subjects but were of similar magnitude.\n                    <jats:italic>Mtb<\/jats:italic>\n                    \u2010specific CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells in LTBI subjects were mostly T\n                    <jats:sub>EMRA<\/jats:sub>\n                    cells (CD45RA\n                    <jats:sup>+<\/jats:sup>\n                    CCR7\n                    <jats:sup>\u2212<\/jats:sup>\n                    ), coexpressing 2B4 and CD160, and in TB patients were mostly T\n                    <jats:sub>EM<\/jats:sub>\n                    cells (CD45RA\n                    <jats:sup>\u2212<\/jats:sup>\n                    CCR7\n                    <jats:sup>\u2212<\/jats:sup>\n                    ), expressing 2B4 but lacking PD\u20101 and CD160. The cytokine profile was not significantly different in both groups. Furthermore,\n                    <jats:italic>Mtb<\/jats:italic>\n                    \u2010specific CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells expressed low levels of perforin and granulysin but contained granzymes A and B. However, in vitro\u2010expanded\n                    <jats:italic>Mtb<\/jats:italic>\n                    \u2010specific CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells expressed perforin and granulysin. Finally,\n                    <jats:italic>Mtb<\/jats:italic>\n                    \u2010specific CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell responses were less frequently detected in extrapulmonary TB compared with pulmonary TB patients.\n                    <jats:italic>Mtb<\/jats:italic>\n                    \u2010specific CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell proliferation was also greater in patients with extrapulmonary compared with pulmonary TB. Thus, the activity of\n                    <jats:italic>Mtb<\/jats:italic>\n                    infection and clinical presentation are associated with distinct profiles of\n                    <jats:italic>Mtb<\/jats:italic>\n                    \u2010specific CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell responses. These results provide new insights in the interaction between\n                    <jats:italic>Mtb<\/jats:italic>\n                    and the host immune response.\n                  <\/jats:p>","DOI":"10.1002\/eji.201243262","type":"journal-article","created":{"date-parts":[[2013,3,4]],"date-time":"2013-03-04T22:54:02Z","timestamp":1362437642000},"page":"1568-1577","source":"Crossref","is-referenced-by-count":177,"title":["<i>Mycobacterium tuberculosis<\/i>\n                    \u2010specific CD8\n                    <sup>+<\/sup>\n                    T cells are functionally and phenotypically different between latent infection and active disease"],"prefix":"10.1002","volume":"43","author":[{"given":"Virginie","family":"Rozot","sequence":"first","affiliation":[{"name":"Division of Immunology and Allergy Centre Hospitalier Universitaire Vaudois University of Lausanne  Lausanne 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Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Perreau","sequence":"additional","affiliation":[{"name":"Division of Immunology and Allergy Centre Hospitalier Universitaire Vaudois University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Lazor\u2010Blanchet","sequence":"additional","affiliation":[{"name":"Division of Occupational Medicine Centre Hospitalier Universitaire Vaudois University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Petruccioli","sequence":"additional","affiliation":[{"name":"National Institute for Infectious Diseases  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem","family":"Hanekom","sequence":"additional","affiliation":[{"name":"South African Tuberculosis Vaccine Initiative University of Cape Town  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delia","family":"Goletti","sequence":"additional","affiliation":[{"name":"National Institute for Infectious Diseases  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre\u2010Alexandre","family":"Bart","sequence":"additional","affiliation":[{"name":"Division of Immunology and Allergy Centre Hospitalier Universitaire Vaudois University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Nicod","sequence":"additional","affiliation":[{"name":"Division of Pneumology Centre Hospitalier Universitaire Vaudois University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Pantaleo","sequence":"additional","affiliation":[{"name":"Division of Immunology and Allergy Centre Hospitalier Universitaire Vaudois University of Lausanne  Lausanne 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