{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:08:00Z","timestamp":1790359680774,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,16]],"date-time":"2014-01-16T00:00:00Z","timestamp":1389830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p>The contribution of antigen\u2010driven B\u2010cell adaptive immune responses within the inflamed muscle of inflammatory myopathies (IMs) is largely unknown. In this study, we investigated the immunoglobulin V<jats:sub>H<\/jats:sub> gene repertoire, somatic hypermutation, clonal diversification, and selection of infiltrating B cells in muscle biopsies from IM patients (dermatomyositis and polymyositis), to determine whether B cells and\/or plasma cells contribute to the associated pathologies of these diseases. The data reveal that Ig V<jats:sub>H<\/jats:sub> gene repertoires of muscle\u2010infiltrating B cells deviate from the normal V<jats:sub>H<\/jats:sub> gene repertoire in individual patients, and differ between different types of IMs. Analysis of somatic mutations revealed clonal diversification of muscle\u2010infiltrating B cells and evidence for a chronic B\u2010cell response within the inflamed muscle. We conclude that muscle\u2010infiltrating B cells undergo selection, somatic hypermutation and clonal diversification in situ during antigen\u2010driven immune responses in patients with IMs, providing insight into the contribution of B cells to the pathological mechanisms of these disorders.<\/jats:p>","DOI":"10.1002\/eji.201343315","type":"journal-article","created":{"date-parts":[[2013,12,16]],"date-time":"2013-12-16T17:54:47Z","timestamp":1387216487000},"page":"585-596","source":"Crossref","is-referenced-by-count":15,"title":["The V<sub>H<\/sub> repertoire and clonal diversification of B cells in inflammatory myopathies"],"prefix":"10.1002","volume":"44","author":[{"given":"Donna","family":"McIntyre","sequence":"first","affiliation":[{"name":"Institute of Infection Immunity and Inflammation Glasgow Biomedical Research Centre University of Glasgow  Glasgow Scotland UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neta S.","family":"Zuckerman","sequence":"additional","affiliation":[{"name":"The Mina and Everard Goodman Faculty of Life Sciences Bar\u2010Ilan University  Ramat\u2010Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Field","sequence":"additional","affiliation":[{"name":"Wolfson Medical School Building University of Glasgow  Glasgow Scotland UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramit","family":"Mehr","sequence":"additional","affiliation":[{"name":"The Mina and Everard Goodman Faculty of Life Sciences Bar\u2010Ilan University  Ramat\u2010Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David I.","family":"Stott","sequence":"additional","affiliation":[{"name":"Institute of Infection Immunity and Inflammation Glasgow Biomedical Research Centre University of Glasgow  Glasgow Scotland UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-199606000-00015"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14368-1"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410160206"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410160207"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.16.9209"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23840"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23822"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020266"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2009.05.010"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.1.221"},{"key":"e_1_2_8_12_1","first-page":"395","volume-title":"Autoimmune Disorders \u2013 Current Concepts and Advances from Bedside to Mechanistic Insight","author":"Stott D.","year":"2011"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2008.06.006"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-7580-4-3"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200207)32:7<1947::AID-IMMU1947>3.0.CO;2-1"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2008.08.005"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2010.07.004"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200939914"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20042483"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20464"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000187124.92826.20"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.1.547"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21739"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh518"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.8.1170"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.4.1935"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.11311"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199812)41:12<2238::AID-ART20>3.0.CO;2-V"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0060001"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200737664"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20062131"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1553"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20062409"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/88732"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.11.7868"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-06-2383"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.12.004"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.143.6.763"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20849"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.11181"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22211"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22603"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn316"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.11.6790"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200838333"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxq441"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxn026"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-006-9056-9"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2003.11.026"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199810)28:10<3384::AID-IMMU3384>3.0.CO;2-T"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00261-3"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.6.3382"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.8.5170"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2005.02.008"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.201343315","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.201343315","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/eji.201343315","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.201343315","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T01:33:31Z","timestamp":1694396011000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.201343315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,16]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1002\/eji.201343315"],"URL":"https:\/\/doi.org\/10.1002\/eji.201343315","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,16]]}}}