{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:38:35Z","timestamp":1788871115850,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,7,3]],"date-time":"2013-07-03T00:00:00Z","timestamp":1372809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004522","name":"TI Pharma","doi-asserted-by":"crossref","award":["T1-214-1"],"award-info":[{"award-number":["T1-214-1"]}],"id":[{"id":"10.13039\/501100004522","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:p>\n                    Innate\u2010like murine B\u20101a cells are well known for their ability to secrete natural IgM. Their non\u2010Ab mediated functions, including Ag presentation to CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\u00a0cells, are less well explored. Using combined adoptive transfer experiments with peptide\u2010pulsed peritoneal cavity (PerC)\u2010derived B\u20101a cells and CFSE\u2010labeled T\u00a0cells, we show that B\u20101a cells present Ag to CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\u00a0cells from the periphery in vivo. In vitro characterization, using co\u2010cultures in which B\u20101a or splenic B cells presented whole OVA protein to OVA\u2010specific Tg T\u00a0cells, shows that B\u20101a cells differentially promote intracellular cytokine\u2010expressing T\u00a0cells. PerC\u2010derived B\u20101a cells increase the percentage of IL\u201010\u2010producing T\u00a0cells along with IL\u20104\u2010 and IFN\u2010\u03b3\u2010producing CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\u00a0cells. These data suggest that B cells in the PerC have the potential to influence peripheral immune responses without the necessity to migrate out of this location. This, to our knowledge previously undescribed, immuno\u2010logical pathway potentially plays a role in the presentation of gut microbiota\u2010derived Ags to peripheral T\u00a0cells.\n                  <\/jats:p>","DOI":"10.1002\/eji.201343418","type":"journal-article","created":{"date-parts":[[2013,5,30]],"date-time":"2013-05-30T03:20:45Z","timestamp":1369884045000},"page":"2317-2326","source":"Crossref","is-referenced-by-count":45,"title":["Peritoneal cavity B\u20101a cells promote peripheral CD4\n                    <sup>+<\/sup>\n                    T\u2010cell activation"],"prefix":"10.1002","volume":"43","author":[{"given":"Bram","family":"Margry","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Immunology Utrecht University Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willemien H.","family":"Wieland","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Immunology Utrecht University Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"van Kooten","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Immunology Utrecht University Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem","family":"van Eden","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Immunology Utrecht University Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Femke","family":"Broere","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Immunology Utrecht University Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201413"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152612800564446"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200737728"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2729"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.4.2046"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901081"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100284"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0700326104"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2901"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2010.00941.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00372"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200636483"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/3.5.467"},{"key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"5503","DOI":"10.4049\/jimmunol.153.12.5503","article-title":"CD43 (S7) expression identifies peripheral B cell subsets","volume":"153","author":"Wells S. 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