{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:14:23Z","timestamp":1779236063020,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,4,16]],"date-time":"2013-04-16T00:00:00Z","timestamp":1366070400000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:p>Cytomegalovirus (<jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content>) infection is widespread in the human population. Normally, in adolescents and adults, prior exposure to <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> can readily be determined by <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content> assays. However, in individuals where antibody production is impaired, such as patients with common variable immunodeficiency disease or in the very young where maternal antibodies are present, diagnosis of <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> infection is problematic using such assays. In this issue of the <jats:italic><jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>uropean <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>ournal of <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>mmunology<\/jats:italic>, a study by <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ester and colleagues [<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>ur J Immunol 2013. 43: 1099\u20101108] using <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010cell immunity as a marker of infection clearly differentiates young children with prior exposure to <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> from those who only have passive maternal antibody. This information will quickly find application in the pretransplant screening of young children for <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> infection and help with the stratification of these children to identify those who are truly <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> negative and are therefore at risk for future <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> infection and disease if receiving an organ from a <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content>\u2010positive donor as discussed in this <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ommentary.<\/jats:p>","DOI":"10.1002\/eji.201343466","type":"journal-article","created":{"date-parts":[[2013,4,16]],"date-time":"2013-04-16T12:04:16Z","timestamp":1366113856000},"page":"886-888","source":"Crossref","is-referenced-by-count":7,"title":["<scp>CMV<\/scp> infected or not <scp>CMV<\/scp> infected: That is the question"],"prefix":"10.1002","volume":"43","author":[{"given":"Vincent C.","family":"Emery","sequence":"first","affiliation":[{"name":"Department of Microbial and Cellular Sciences University of Surrey  Guildford Surrey UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4,16]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2006.00618.x"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcr262"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.2.177"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050882"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201242752"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.295"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000150510"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01809-09"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00467-12"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2006.03209.x"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.02.011"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.04.001"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/314939"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201243100"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000083894.61333.56"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.05.049"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.201343466","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.201343466","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T20:47:32Z","timestamp":1696538852000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.201343466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1002\/eji.201343466"],"URL":"https:\/\/doi.org\/10.1002\/eji.201343466","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4]]}}}