{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:48:23Z","timestamp":1770749303792,"version":"3.50.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,11,15]],"date-time":"2013-11-15T00:00:00Z","timestamp":1384473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p>We and others have previously shown that <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201012 is indispensable for immunity and is required for the optimal antiparasitic activity of antimonials in experimental visceral leishmaniasis caused by <jats:italic><jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>eishmania donovani<\/jats:italic>. Here we investigated the role of <jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>4 in immunity against <jats:italic><jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>. donovani<\/jats:italic> using <jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>4 knockout mice and also determined the effect of <jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>4 deficiency in response to antimonial therapy. Upon infection with <jats:italic><jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>. donovani<\/jats:italic>, <jats:italic>stat4<jats:sup>\u2212\/\u2212<\/jats:sup><\/jats:italic> <jats:styled-content style=\"fixed-case\">BALB<\/jats:styled-content>\/c and <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6 mice showed enhanced susceptibility to <jats:italic><jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>eishmania<\/jats:italic> during late time points of infection which was associated with a marked reduction in Th1 responses and hepatic immunopathology. Interestingly, these defects in <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h1 responses in <jats:italic>stat4<jats:sup>\u2212\/\u2212<\/jats:sup><\/jats:italic> did not impair the antimonial chemotherapy as both <jats:italic>stat4<jats:sup>\u2212\/\u2212<\/jats:sup><\/jats:italic> and <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content> mice showed comparable levels of parasite clearance from the liver and spleen. These findings highlight the role of <jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>4 in immunity to <jats:italic><jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>. donovani<\/jats:italic> infection and also provide evidence that <jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>4 is dispensable for antimonial\u2010based chemotherapy.<\/jats:p>","DOI":"10.1002\/eji.201343477","type":"journal-article","created":{"date-parts":[[2013,11,13]],"date-time":"2013-11-13T20:06:46Z","timestamp":1384373206000},"page":"450-459","source":"Crossref","is-referenced-by-count":19,"title":["<scp>STAT<\/scp>4 is critical for immunity but not for antileishmanial activity of antimonials in experimental visceral leishmaniasis"],"prefix":"10.1002","volume":"44","author":[{"given":"Steve","family":"Oghumu","sequence":"first","affiliation":[{"name":"Department of Pathology Ohio State University Medical Center  Columbus OH USA"},{"name":"Department of Oral Biology Ohio State University College of Dentistry  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaurav","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Pathology Ohio State University Medical Center  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidi M.","family":"Snider","sequence":"additional","affiliation":[{"name":"Department of Pathology Ohio State University Medical Center  Columbus OH USA"},{"name":"Department of Oral Biology Ohio State University College of Dentistry  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay","family":"Varikuti","sequence":"additional","affiliation":[{"name":"Department of Pathology Ohio State University Medical Center  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9sar A.","family":"Terrazas","sequence":"additional","affiliation":[{"name":"Department of Pathology Ohio State University Medical Center  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracey L.","family":"Papenfuss","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Ohio State University Medical Center  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark H.","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Indiana University School of Medicine  Indianapolis IN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhay R.","family":"Satoskar","sequence":"additional","affiliation":[{"name":"Department of Pathology Ohio State University Medical Center  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.icb7100011"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/107999000312748"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/516482"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.4049\/jimmunol.153.6.2533","article-title":"Parasite\u2010induced IL\u201012 stimulates early IFN\u2010gamma synthesis and resistance during acute infection with \n                     Toxoplasma gondii","volume":"153","author":"Gazzinelli R. 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