{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T02:15:24Z","timestamp":1722478524690},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,8,27]],"date-time":"2013-08-27T00:00:00Z","timestamp":1377561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:p><jats:styled-content style=\"fixed-case\">NK T<\/jats:styled-content> cells<jats:styled-content style=\"fixed-case\">(NKT<\/jats:styled-content> cells) share functional characteristics and homing properties that are distinct from conventional <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells. In this study, we investigated the contribution of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>28 in the functional development of \u03b3\u03b4 <jats:styled-content style=\"fixed-case\">NKT<\/jats:styled-content> and \u03b1\u03b2 <jats:styled-content style=\"fixed-case\">NKT<\/jats:styled-content> cells in mice. We show that <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>28 promotes the thymic maturation of promyelocytic leukemia zinc finger<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">NKT<\/jats:styled-content> cells and upregulation of <jats:styled-content style=\"fixed-case\">LFA<\/jats:styled-content>\u20101 expression on <jats:styled-content style=\"fixed-case\">NKT<\/jats:styled-content> cells. We demonstrate that the developmental defect of \u03b3\u03b4 <jats:styled-content style=\"fixed-case\">NKT<\/jats:styled-content> cells in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>28\u2010deficient mice is cell autonomous. Moreover, we show in both wild\u2010type <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6 mice and in downstream of tyrosine kinase\u20101 transgenic mice, a mouse model with increased numbers of \u03b3\u03b4 <jats:styled-content style=\"fixed-case\">NKT<\/jats:styled-content> cells, that <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>28\u2010mediated regulation of thymic <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">NKT<\/jats:styled-content> cells promotes the differentiation of eomesodermin<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>44<jats:sup>high<\/jats:sup> innate\u2010like <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells. These findings reveal a previously unappreciated mechanism by which <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>28 controls <jats:styled-content style=\"fixed-case\">NKT<\/jats:styled-content>\u2010cell homeostasis and the size of the innate\u2010like <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010cell pool.<\/jats:p>","DOI":"10.1002\/eji.201343627","type":"journal-article","created":{"date-parts":[[2013,7,30]],"date-time":"2013-07-30T07:39:11Z","timestamp":1375169951000},"page":"3017-3027","source":"Crossref","is-referenced-by-count":2,"title":["<scp>CD<\/scp>28 controls the development of innate\u2010like <scp>CD<\/scp>8<sup>+<\/sup><scp>T<\/scp> cells by promoting the functional maturation of <scp>NKT<\/scp> cells"],"prefix":"10.1002","volume":"43","author":[{"given":"Mitra","family":"Yousefi","sequence":"first","affiliation":[{"name":"Institut National de la Recherche Scientifique\u2010Institut Armand\u2010Frappier Universit\u00e9 du Qu\u00e9bec Laval Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascale","family":"Duplay","sequence":"additional","affiliation":[{"name":"Institut National de la Recherche Scientifique\u2010Institut Armand\u2010Frappier Universit\u00e9 du Qu\u00e9bec Laval Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2010.00962.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni710"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.180.3.1097"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0903895106"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201242421"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2010.12.016"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2116"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201142109"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2247"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202531"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1641"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.07.011"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2010.12.004"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202145"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2230"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2005.01.002"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202435"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.2.907"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.4.2276"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002703"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903218"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20102630"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.5.2397"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1069017"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.07.013"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1898"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103729"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002825"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.21.8221"},{"key":"e_1_2_7_31_1","doi-asserted-by":"crossref","first-page":"5094","DOI":"10.4049\/jimmunol.162.9.5094","article-title":"Critical role of leukocyte function\u2010associated antigen\u20101 in liver accumulation of CD4+\n                  NKT cells","volume":"162","author":"Emoto M.","year":"1999","journal-title":"J. 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