{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T02:31:47Z","timestamp":1779244307219,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,6,21]],"date-time":"2013-06-21T00:00:00Z","timestamp":1371772800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2013,6]]},"abstract":"Vitamin A<\/jats:styled-content> and its metabolite retinoic acid influence various aspects of immunity. Although the capacity of vitamin A to condition intestinal CD<\/jats:styled-content>103+<\/jats:sup> DC<\/jats:styled-content>s to imprint tissue\u2010specific homing programs onto activated lymphocytes is well documented, it is unclear whether vitamin A<\/jats:styled-content> also regulates DC<\/jats:styled-content> populations in other tissues. A study published in this issue of the E<\/jats:styled-content>uropean J<\/jats:styled-content>ournal of I<\/jats:styled-content>mmunology<\/jats:italic>, Beijer et al. [Eur. J. Immunol. 2013. 43: 1608\u20131616] now demonstrates that vitamin A<\/jats:styled-content> exerts profound effects on the subset composition of splenic DC<\/jats:styled-content>s. By resolving that splenic ESAM<\/jats:styled-content>hi<\/jats:sup> CD<\/jats:styled-content>11bhi<\/jats:sup> DC<\/jats:styled-content>s are preferentially responsive to regulation by vitamin A<\/jats:styled-content>, these novel insights not only further support the notion that ESAM<\/jats:styled-content> expression marks two distinct lineages of splenic CD<\/jats:styled-content>11bhi<\/jats:sup> DC<\/jats:styled-content>s, but also provide an important extension to our understanding of how vitamin A<\/jats:styled-content> influences the immune system.<\/jats:p>","DOI":"10.1002\/eji.201343631","type":"journal-article","created":{"date-parts":[[2013,5,10]],"date-time":"2013-05-10T07:00:58Z","timestamp":1368169258000},"page":"1441-1444","source":"Crossref","is-referenced-by-count":4,"title":["Vitamin A<\/scp> notches up CD<\/scp>11bhi<\/sup>DC<\/scp> development"],"prefix":"10.1002","volume":"43","author":[{"given":"Angus T.","family":"Stock","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology The University of Melbourne Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sammy","family":"Bedoui","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology The University of Melbourne Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,21]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1996"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-100311-102839"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-020711-074950"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2009.00870.x"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100223"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100348"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1136080"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2010.34"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802286"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3149"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.08.013"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20060565"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201343325"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/neu.20242"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2012.73"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20011502"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1132742"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.11.6592"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.16.9118"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032447"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.08.011"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.12.016"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2555"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.201343631","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.201343631","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T00:28:49Z","timestamp":1696552129000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.201343631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1002\/eji.201343631"],"URL":"https:\/\/doi.org\/10.1002\/eji.201343631","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6]]}}}