{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:50:40Z","timestamp":1792594240667,"version":"4.5.0"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,12,4]],"date-time":"2013-12-04T00:00:00Z","timestamp":1386115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p>Leprosy is a chronic infectious disease caused by <jats:italic><jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ycobacterium leprae<\/jats:italic>. Fox<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>3 have been shown to have important implications in various diseases. The present study describes the mechanism of action of <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ox<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>3 in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>25<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells derived from leprosy patients. Increased molecular interactions of <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ox<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>3 with histone deacetylases 7\/9 in the nucleus of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>25<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells derived from borderline lepromatous leprosy\/lepromatous leprosy (<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">LL<\/jats:styled-content>) patients were found to be responsible for <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ox<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>3\u2010driven immune suppression activities during the progression of leprosy. Further, downregulation of <jats:styled-content style=\"fixed-case\">CTLA<\/jats:styled-content>\u20104 and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>25 genes in si<jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ox<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>3\u2010treated <jats:styled-content style=\"fixed-case\">PBMC<\/jats:styled-content>s derived from <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">LL<\/jats:styled-content> patients elucidated the transcription\u2010activating nature of <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ox<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>3. This observation was supported by direct binding of <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ox<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>3 to the promoter region of the <jats:styled-content style=\"fixed-case\">CTLA<\/jats:styled-content>\u20104 and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>25 genes, and <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ox<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>3's molecular interaction with histone acetyl transferases. The study also revealed that the increased expression of mi<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>155 in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>25<jats:sup>+<\/jats:sup> cells from <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">LL<\/jats:styled-content> governs the competitive fitness of these cells. Again, reduced <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>nnexin <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content> &amp; propidium iodide staining and <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ur77 expression, and concomitantly increased <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>i\u201067 positivity suggested that <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>25<jats:sup>+<\/jats:sup> cells derived from <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">LL<\/jats:styled-content> patients are more competitively fit than those from borderline tuberculoid leprosy\/tuberculoid leprosy and healthy controls. Taken together, the study shows the orchestration of <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ox<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>3 leading to competitive fitness of <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>reg cells in leprosy.<\/jats:p>","DOI":"10.1002\/eji.201343649","type":"journal-article","created":{"date-parts":[[2013,11,11]],"date-time":"2013-11-11T06:42:52Z","timestamp":1384152172000},"page":"431-439","source":"Crossref","is-referenced-by-count":22,"title":["Fox<scp>P<\/scp>3 provides competitive fitness to <scp>CD<\/scp>4<sup>+<\/sup><scp>CD<\/scp>25<sup>+<\/sup><scp>T<\/scp> cells in leprosy patients via transcriptional regulation"],"prefix":"10.1002","volume":"44","author":[{"given":"Sudhir","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Biochemistry All India Institute of Medical Sciences (AIIMS)  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raza Ali","family":"Naqvi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry All India Institute of Medical Sciences (AIIMS)  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riyasat","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Biochemistry All India Institute of Medical Sciences (AIIMS)  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richa","family":"Rani","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Indian Institute of Technology (IIT)  Roorkee UT India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neena","family":"Khanna","sequence":"additional","affiliation":[{"name":"Department of Dermatovenereology All India Institute of Medical Sciences (AIIMS)  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. N.","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Biochemistry All India Institute of Medical Sciences (AIIMS)  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,4]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Leprosy for Medical Practitioners and Paramedical Workers","author":"Yawalkar S. J.","year":"2009"},{"key":"e_1_2_7_3_1","first-page":"255","article-title":"Classification of leprosy according to immunity: a five\u2010group system","volume":"34","author":"Ridley D.S.","year":"1966","journal-title":"Int. J. Lepr. Other. Mycobact. 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