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To investigate the impact of Bcl\u20103 on B\u2010cell maturation and regulation, we generated mice that overexpress Bcl\u20103 specifically in B cells. Interestingly, these mice lack marginal zone B cells and exhibit a significant reduction in the number of B\u20101 B cells. Further, B cells from these mice are impaired in their proliferative capacity. Our data demonstrate that the overexpression of the transcription factor Bcl\u20103 inhibits germinal center formation, marginal zone B\u2010cell development, and affects the B\u20101 B\u2010cell compartment.<\/jats:p>","DOI":"10.1002\/eji.201343655","type":"journal-article","created":{"date-parts":[[2013,11,18]],"date-time":"2013-11-18T22:30:04Z","timestamp":1384813804000},"page":"545-552","source":"Crossref","is-referenced-by-count":21,"title":["Overexpression of Bcl\u20103 inhibits the development of marginal zone B cells"],"prefix":"10.1002","volume":"44","author":[{"given":"Nadine","family":"H\u00f6velmeyer","sequence":"first","affiliation":[{"name":"Institute for Molecular Medicine Johannes Gutenberg\u2010University of Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus A.","family":"W\u00f6rns","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University Medical Center of the Johannes Gutenberg\u2010University of Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Reissig","sequence":"additional","affiliation":[{"name":"Institute for Molecular Medicine Johannes Gutenberg\u2010University of Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Adams\u2010Quack","sequence":"additional","affiliation":[{"name":"Institute for Molecular Medicine Johannes Gutenberg\u2010University of Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Leclaire","sequence":"additional","affiliation":[{"name":"Institute for Molecular Medicine Johannes Gutenberg\u2010University of Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Hahn","sequence":"additional","affiliation":[{"name":"Institute for Molecular Medicine Johannes Gutenberg\u2010University of Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"W\u00f6rtge","sequence":"additional","affiliation":[{"name":"Institute for Molecular Medicine Johannes Gutenberg\u2010University of Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexei","family":"Nikolaev","sequence":"additional","affiliation":[{"name":"Institute for Molecular Medicine Johannes Gutenberg\u2010University of Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R.","family":"Galle","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University Medical Center of the Johannes Gutenberg\u2010University of Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ari","family":"Waisman","sequence":"additional","affiliation":[{"name":"Institute for Molecular Medicine Johannes Gutenberg\u2010University of Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/348076a0"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90347-H"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90401-B"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.7.7b.1354"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1128\/iai.61.4.1523-1530.1993","article-title":"The immunodominant 90\u2010kilodalton protein is localized on the terminal tip structure of Mycoplasma pneumoniae","volume":"61","author":"Franzoso G.","year":"1993","journal-title":"Infect. 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