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In vitro studies revealed that activated <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> cells differentiated into <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>rz<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\u2010expressing <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>s when co\u2010cultured with macrophages and follicular helper <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells. This effect could be reproduced on combined stimulation of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201015 (produced by macrophages) and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201021 (produced by <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> follicular helper cells) in a <jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>3\u2010dependent manner. Whereas <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201021 triggers the transcription of m<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> of <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>rz<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201015 synergizes the translation of <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>rz<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> proteins. The precise role of <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>rz<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content> biology remains to be understood and studies in mice will not help as their <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>s do not express <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>rz<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>.<\/jats:p>","DOI":"10.1002\/eji.201343711","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T01:05:19Z","timestamp":1381539919000},"page":"275-284","source":"Crossref","is-referenced-by-count":35,"title":["Human plasma cells express granzyme <scp>B<\/scp>"],"prefix":"10.1002","volume":"44","author":[{"given":"Wei","family":"Xu","sequence":"first","affiliation":[{"name":"Baylor Institute for Immunology Research  Dallas TX 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