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In response to allergen presentation by airway <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s, <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010helper lymphocytes of the adaptive immune system control many aspects of the disease through secretion of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20105, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201013, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017, and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201022, and these are counterbalanced by cytokines produced by <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>reg cells. Many cells of the innate immune system such as mast cells, basophils, neutrophils, eosinophils, and innate lymphoid cells also play an important role in disease pathogenesis. Barrier epithelial cells are being ever more implicated in disease pathogenesis than previously thought, as these cells have in recent years been shown to sense exposure to allergens via pattern recognition receptors and to activate conventional and inflammatory\u2010type <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s and other innate immune cells through the secretion of thymic stromal lymphopoietin, granulocyte\u2010macrophage colony stimulating factor, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201033, and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201025. 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