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We have recently shown that cognate interactions between Foxp3<jats:sup>+<\/jats:sup> Tregs and steady\u2010state DCs are crucial to maintain the tolerogenic potential of DCs. Using DIETER mice, which allow the induction of antigen presentation selectively on DCs without altering their maturation status, we show here that breakdown of CD8<jats:sup>+<\/jats:sup> T\u2010cell tolerance, which ensues after depletion of suppressive CD4<jats:sup>+<\/jats:sup> T cells, is driven by a positive feedback loop in which autoreactive CD8<jats:sup>+<\/jats:sup> T cells activate DCs via CD40. These data identify ligation of CD40 on DCs as a stimulus that promotes autoreactive T\u2010cell priming when regulatory T\u2010cell suppression fails and suggest that feedback from autoreactive T cells to DCs may contribute to the well\u2010documented involvement of CD40 in many autoimmune diseases.<\/jats:p>","DOI":"10.1002\/eji.201343738","type":"journal-article","created":{"date-parts":[[2014,1,14]],"date-time":"2014-01-14T16:00:37Z","timestamp":1389715237000},"page":"1099-1107","source":"Crossref","is-referenced-by-count":8,"title":["A CD40\/CD40L feedback loop drives the breakdown of CD8<sup>+<\/sup><scp>T<\/scp>\u2010cell tolerance following depletion of suppressive CD4<sup>+<\/sup> T cells"],"prefix":"10.1002","volume":"44","author":[{"given":"Sabine","family":"Muth","sequence":"first","affiliation":[{"name":"Institute for Immunology University Medical Center of the Johannes Gutenberg University Mainz  Mainz Germany"},{"name":"Research Center for Immunology (FZI)  Mainz 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