{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:40:58Z","timestamp":1786977658413,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,1,13]],"date-time":"2014-01-13T00:00:00Z","timestamp":1389571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2014,3]]},"abstract":"\n Most differentiated\n CD<\/jats:styled-content>\n 8\n +<\/jats:sup>\n T<\/jats:styled-content>\n cells die off at the end of an infection, revealing two main subsets of memory T cells \u2014 central and effector memory \u2014 which can be found in lymphoid tissues or circulating through nonlymphoid organs, respectively. The cell intrinsic regulation of the differentiation of\n CD<\/jats:styled-content>\n 8\n +<\/jats:sup>\n T<\/jats:styled-content>\n cells to effector and central memory remains poorly studied. Herein, we describe a novel role of the\n ETS<\/jats:styled-content>\n transcription factor\n ELF<\/jats:styled-content>\n 4 in the development and function of memory\n CD<\/jats:styled-content>\n 8\n +<\/jats:sup>\n T<\/jats:styled-content>\n cells following infection with\n \n L<\/jats:styled-content>\n isteria monocytogenes\n <\/jats:italic>\n . Adoptively transferred\n \n Elf4\n \u2212\/\u2212<\/jats:sup>\n <\/jats:italic>\n na\u00efve\n CD<\/jats:styled-content>\n 8\n +<\/jats:sup>\n T<\/jats:styled-content>\n cells produced lower numbers of effector memory\n CD<\/jats:styled-content>\n 8\n +<\/jats:sup>\n T<\/jats:styled-content>\n cells despite a normal pool of central memory. This was caused by suboptimal priming and decreased survival of\n CD<\/jats:styled-content>\n 8\n +<\/jats:sup>\n T<\/jats:styled-content>\n cells at the peak of response while enhanced\n N<\/jats:styled-content>\n otch1 signaling and upregulation of eomesodermin correlated with \u201cnormal\u201d development of\n \n E<\/jats:styled-content>\n lf4\n \u2212\/\u2212<\/jats:sup>\n <\/jats:italic>\n central memory. Finally, loss of\n ELF<\/jats:styled-content>\n 4 impaired the expansion of both central and effector memory\n CD<\/jats:styled-content>\n 8\n +<\/jats:sup>\n T<\/jats:styled-content>\n cells in a recall response by also activating\n N<\/jats:styled-content>\n otch1 signaling. Altogether,\n ELF<\/jats:styled-content>\n 4 emerges as a novel transcriptional regulator of\n CD<\/jats:styled-content>\n 8\n +<\/jats:sup>\n T<\/jats:styled-content>\n \u2010cell differentiation in response to infection.\n <\/jats:p>","DOI":"10.1002\/eji.201343775","type":"journal-article","created":{"date-parts":[[2013,12,13]],"date-time":"2013-12-13T19:22:42Z","timestamp":1386962562000},"page":"715-727","source":"Crossref","is-referenced-by-count":15,"title":["Transcription factor\n ELF<\/scp>\n 4 promotes development and function of memory\n CD<\/scp>\n 8\n +<\/sup>\n T<\/scp>\n cells in\n \n L<\/scp>\n isteria monocytogenes\n <\/i>\n infection"],"prefix":"10.1002","volume":"44","author":[{"given":"Maksim","family":"Mamonkin","sequence":"first","affiliation":[{"name":"Department of Pathology & Immunology Baylor College of Medicine Texas Children's Hospital Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Puppi","sequence":"additional","affiliation":[{"name":"Department of Pathology & Immunology Baylor College of Medicine Texas Children's Hospital Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Daniel","family":"Lacorazza","sequence":"additional","affiliation":[{"name":"Department of Pathology & Immunology Baylor College of Medicine Texas Children's Hospital Houston TX USA"},{"name":"Department of Pediatrics Baylor College of Medicine Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2010.00901.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.25.022106.141548"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1461"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00404"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxq053"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.22.012703.104702"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201041377"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2005.02.007"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10003"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.11.6533"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1718"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1268"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.07.010"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni802"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.06.021"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.05.014"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002042"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1159806"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802598"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.11.7515"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.08.002"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.10.010"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000718"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1730"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00422-3"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5403.845"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.07.017"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200526024"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102335"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002145"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20081242"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.09.017"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2538"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.01.008"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.11.012"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.11.010"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200318020"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.20.10872-10880.2003"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(04)00081-0"},{"key":"e_1_2_7_41_1","doi-asserted-by":"crossref","first-page":"3780","DOI":"10.1182\/blood.V92.10.3780","article-title":"Efficient and rapid induction of a chronic myelogenous leukemia\u2010like myeloproliferative disease in mice receiving P210 bcr\/abl\u2010transduced bone marrow","volume":"92","author":"Pear W. 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