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Under steady\u2010state conditions, and even after systemic stimulation with LPS, CCL17 is not expressed in resident splenic DCs as opposed to CD8\u03b1<jats:sup>\u2212<\/jats:sup>CD11b<jats:sup>+<\/jats:sup> LN DCs, which produce large amounts of CCL17 in particular after maturation. Upon systemic NKT cell activation through \u03b1\u2010galactosylceramide stimulation however, CCL17 can be upregulated in both CD8\u03b1<jats:sup>\u2212<\/jats:sup> and CD8\u03b1<jats:sup>+<\/jats:sup> splenic DC subsets and enhances cross\u2010presentation of exogenous antigens. Based on genome\u2010wide expression profiling, we now show that splenic CD11b<jats:sup>+<\/jats:sup> DCs are susceptible to IFN\u2010\u03b3\u2010mediated suppression of CCL17, whereas LN CD11b<jats:sup>+<\/jats:sup>CCL17<jats:sup>+<\/jats:sup> DCs downregulate the IFN\u2010\u03b3R and are much less responsive to IFN\u2010\u03b3. Under inflammatory conditions, particularly in the absence of IFN\u2010\u03b3 signaling in IFN\u2010\u03b3RKO mice, CCL17 expression is strongly induced in a major proportion of splenic DCs by the action of GM\u2010CSF in concert with IL\u20104. Our findings demonstrate that the local cytokine milieu and differential cytokine responsiveness of DC subsets regulate lymphoid organ specific immune responses at the level of chemokine expression.<\/jats:p>","DOI":"10.1002\/eji.201343820","type":"journal-article","created":{"date-parts":[[2013,10,18]],"date-time":"2013-10-18T07:04:34Z","timestamp":1382079874000},"page":"500-510","source":"Crossref","is-referenced-by-count":22,"title":["Cytokine\u2010dependent regulation of dendritic cell differentiation in the splenic microenvironment"],"prefix":"10.1002","volume":"44","author":[{"given":"Theresa","family":"Globisch","sequence":"first","affiliation":[{"name":"Department of Molecular Immunology IUF \u2014 Leibniz Research Institute for Environmental Medicine  D\u00fcsseldorf Germany"},{"name":"Immunology and Environment Life and Medical Sciences (LIMES) Institute University of Bonn  Bonn 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