{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:02:42Z","timestamp":1791154962687,"version":"4.1.0"},"reference-count":61,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T00:00:00Z","timestamp":1392768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2014,3]]},"abstract":"The atypical chemokine receptor CXCR<\/jats:styled-content>7 binds the chemokines CXCL<\/jats:styled-content>12 and CXCL<\/jats:styled-content>11. The receptor is widely expressed and was shown to tune CXCR<\/jats:styled-content>12\u2010induced responses of CXCR<\/jats:styled-content>4. Here, the function of CXCR<\/jats:styled-content>7 was examined at late stages of human B<\/jats:styled-content>\u2010cell maturation, when B<\/jats:styled-content>\u00a0cells differentiate into A<\/jats:styled-content>b\u2010secreting plasmablasts. We identified two populations of CXCR<\/jats:styled-content>7+<\/jats:sup> cells in tonsillar lymphocytes, one being presumably memory B<\/jats:styled-content>\u00a0cells or early plasmablasts (FSClow<\/jats:sup>CD19+<\/jats:sup>CD38mid<\/jats:sup>) and the other being plasmablasts or early plasma cells (FSChigh<\/jats:sup>CD19+<\/jats:sup>CD38+<\/jats:sup>). CXCR<\/jats:styled-content>7 is expressed on CD<\/jats:styled-content>19+<\/jats:sup>CD<\/jats:styled-content>27+<\/jats:sup> memory B<\/jats:styled-content>\u00a0cells, on CD<\/jats:styled-content>19+<\/jats:sup>CD<\/jats:styled-content>38+<\/jats:sup>CD<\/jats:styled-content>138\u2212<\/jats:sup> and intracellular immunoglobulin high plasmablasts, but not on CD<\/jats:styled-content>19+<\/jats:sup>CD<\/jats:styled-content>138+<\/jats:sup>icIghigh<\/jats:sup> plasma cells. The differential expression pattern suggests a potential contribution of the scavenger receptor in final B<\/jats:styled-content>\u2010cell maturation. On in vitro differentiating B<\/jats:styled-content>\u00a0cells, we found a marked inverse correlation between CXCR<\/jats:styled-content>7 and CXCR<\/jats:styled-content>5 cell surface levels, whereas expression of CXCR<\/jats:styled-content>4 remained almost constant. Migration assays performed with tonsillar mononuclear cells or in vitro differentiated cells revealed that inhibition of CXCR<\/jats:styled-content>7 markedly increases chemotaxis toward CXCL<\/jats:styled-content>12, especially at late stages of B<\/jats:styled-content>\u2010cell maturation. Chemotaxis was attenuated in the presence of CXCR<\/jats:styled-content>4 antagonists, confirming that migration is CXCR<\/jats:styled-content>4 mediated. Our findings unequivocally demonstrate a novel role for CXCR<\/jats:styled-content>7 in regulating the migration of plasmablasts during B<\/jats:styled-content>\u2010cell maturation.<\/jats:p>","DOI":"10.1002\/eji.201343907","type":"journal-article","created":{"date-parts":[[2013,11,20]],"date-time":"2013-11-20T14:06:57Z","timestamp":1384956417000},"page":"694-705","source":"Crossref","is-referenced-by-count":40,"title":["CXCR<\/scp>7 influences the migration of B<\/scp> cells during maturation"],"prefix":"10.1002","volume":"44","author":[{"given":"Marie\u2010Luise","family":"Humpert","sequence":"first","affiliation":[{"name":"Institute for Research in Biomedicine Bellinzona Switzerland"},{"name":"Graduate School for Cellular and Biomedical Sciences, University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dora","family":"Pinto","sequence":"additional","affiliation":[{"name":"Institute for Research in Biomedicine Bellinzona 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