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Extending this concept, recent evidence suggests that <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells also exist as nonmigratory memory cells that provide local immune protection in a broad range of peripheral tissues, including barrier locations such as skin and mucosa. In this issue of the <jats:italic><jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>uropean <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>ournal of <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>mmunology<\/jats:italic>, <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ircher and colleagues [Eur. J. Immunol. 2013. 43: 2295\u20132304] demonstrate, for the first time, the existence of such permanently tissue\u2010resident <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> memory <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content><jats:sub>RM<\/jats:sub>) cells in a primary lymphoid organ, the thymus. <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content><jats:sub>RM<\/jats:sub> cells in this location provide potent local immunity, which may help to preserve thymic integrity and normal <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010cell development in the face of infection with thymus\u2010invading 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