{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:03:23Z","timestamp":1791223403511,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,5,21]],"date-time":"2014-05-21T00:00:00Z","timestamp":1400630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["093748\/Z\/10\/Z"],"award-info":[{"award-number":["093748\/Z\/10\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:p>To investigate the importance of OX40 signals for physiological CD4<jats:sup>+<\/jats:sup> T\u2010cell responses, an endogenous antigen\u2010specific population of CD4<jats:sup>+<\/jats:sup> T\u00a0cells that recognise the 2W1S peptide was assessed and temporal control of OX40 signals was achieved using blocking or agonistic antibodies (Abs) in vivo. Following infection with <jats:italic>Listeria monocytogenes<\/jats:italic> expressing 2W1S peptide, OX40 was briefly expressed by the responding 2W1S\u2010specific CD4<jats:sup>+<\/jats:sup> T\u00a0cells, but only on a subset that co\u2010expressed effector cell markers. This population was specifically expanded by Ab\u2010ligation of OX40 during priming, which also caused skewing of the memory response towards effector memory cells. Strikingly, this greatly enhanced effector response was accompanied by the loss of T follicular helper (TFH) cells and germinal centres. Mice deficient in OX40 and CD30 showed normal generation of TFH cells but impaired numbers of 2W1S\u2010specific effector cells. OX40 was not expressed by 2W1S\u2010specific memory cells, although it was rapidly up\u2010regulated upon challenge whereupon Ab\u2010ligation of OX40 specifically affected the effector subset. In summary, these data indicate that for CD4<jats:sup>+<\/jats:sup> T\u00a0cells, OX40 signals are important for generation of effector T\u00a0cells rather than TFH cells in this response to acute bacterial infection.<\/jats:p>","DOI":"10.1002\/eji.201344211","type":"journal-article","created":{"date-parts":[[2014,4,25]],"date-time":"2014-04-25T17:29:42Z","timestamp":1398446982000},"page":"2437-2447","source":"Crossref","is-referenced-by-count":16,"title":["OX40 controls effector CD4<sup>+<\/sup> T\u2010cell expansion, not follicular T helper cell generation in acute <i>Listeria<\/i> infection"],"prefix":"10.1002","volume":"44","author":[{"given":"Clare L.","family":"Marriott","sequence":"first","affiliation":[{"name":"MRC Centre for Immune Regulation Institute for Biomedical Research College of Medical and Dental Sciences University of Birmingham  Birmingham United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma C.","family":"Mackley","sequence":"additional","affiliation":[{"name":"MRC Centre for Immune Regulation Institute for Biomedical Research College of Medical and Dental Sciences University of Birmingham  Birmingham United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Babraham Institute Babraham Research Campus  Cambridge United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Veldhoen","sequence":"additional","affiliation":[{"name":"Babraham Institute Babraham Research Campus  Cambridge United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Yagita","sequence":"additional","affiliation":[{"name":"Department of Immunology Juntendo University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Withers","sequence":"additional","affiliation":[{"name":"MRC Centre for Immune Regulation Institute for Biomedical Research College of Medical and Dental Sciences University of Birmingham  Birmingham United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.10.5944"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-030409-101243"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"6510","DOI":"10.4049\/jimmunol.161.12.6510","article-title":"Ox\u201040 ligand: a potent costimulatory molecule for sustaining primary CD4 T\u00a0cell responses","volume":"161","author":"Gramaglia I.","year":"1998","journal-title":"J. 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