{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:40:58Z","timestamp":1786977658525,"version":"build-2736575974"},"reference-count":55,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,4,10]],"date-time":"2014-04-10T00:00:00Z","timestamp":1397088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:p>\n                    The role of mineralocorticoid receptors (MRs) in human T\u2010cell migration is not yet understood. We have recently shown that the MR antagonist spironolactone selectively increases the numbers of circulating na\u00efve and central memory T\u00a0cells during early sleep, which is the time period in the 24 h cycle hallmarked by predominant MR activation. To investigate whether this effect is specific to spironolactone's blockade of MRs and to study the underlying molecular mechanisms, healthy humans were given the selective MR\u2010agonist fludrocortisone or placebo and numbers of eight T\u2010cell subsets and their CD62L and CXCR4 expression were analyzed. Fludrocortisone selectively reduced counts of na\u00efve CD4\n                    <jats:sup>+<\/jats:sup>\n                    , central memory CD4\n                    <jats:sup>+<\/jats:sup>\n                    , and na\u00efve CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u00a0cells and increased CXCR4 expression on the na\u00efve subsets. In complementing in vitro studies, fludrocortisone enhanced CXCR4 and CD62L expression, which was counteracted by spironolactone. Incubation of na\u00efve T\u00a0cells with spironolactone alone reduced CD62L and CCR7 expression. Our results indicate a regulatory influence of MR signaling on human T\u2010cell migration and suggest a role for endogenous aldosterone in the redistribution of T\u2010cell subsets to lymph nodes, involving CD62L, CCR7, and CXCR4. Facilitation of T\u2010cell homing following sleep\u2010dependent aldosterone release might thus essentially contribute to sleep's well\u2010known role in supporting adaptive immunity.\n                  <\/jats:p>","DOI":"10.1002\/eji.201344265","type":"journal-article","created":{"date-parts":[[2014,3,4]],"date-time":"2014-03-04T20:56:44Z","timestamp":1393966604000},"page":"1759-1769","source":"Crossref","is-referenced-by-count":29,"title":["Mineralocorticoid receptor signaling reduces numbers of circulating human na\u00efve T\u00a0cells and increases their CD62L, CCR7, and CXCR4 expression"],"prefix":"10.1002","volume":"44","author":[{"given":"Luciana","family":"Besedovsky","sequence":"first","affiliation":[{"name":"Department of Medical Psychology and Behavioral Neurobiology University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Linz","sequence":"additional","affiliation":[{"name":"Department of Neuroendocrinology University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Born","sequence":"additional","affiliation":[{"name":"Department of Medical Psychology and Behavioral Neurobiology University of T\u00fcbingen  T\u00fcbingen Germany"},{"name":"Center for Integrative Neuroscience University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Lange","sequence":"additional","affiliation":[{"name":"Department of Neuroendocrinology University of L\u00fcbeck  L\u00fcbeck Germany"},{"name":"Department of Internal Medicine I University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0889-1591(92)90011-C"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/brbi.1994.1006"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.4049\/jimmunol.157.4.1638","article-title":"Stress\u2010induced changes in blood leukocyte distribution. 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