{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:21:36Z","timestamp":1791397296533,"version":"4.3.3"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,11,13]],"date-time":"2014-11-13T00:00:00Z","timestamp":1415836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["FN 310030\u00e2\u20ac\u201c144072"],"award-info":[{"award-number":["FN 310030\u00e2\u20ac\u201c144072"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>Psoriasis is a T\u2010cell\u2010mediated skin autoimmune disease characterized by the aberrant activation of dermal dendritic cells (DCs) and the sustained epidermal expression of antimicrobial peptides. We have previously identified a link between these two events by showing that the cathelicidin antimicrobial peptide LL37 has the ability to trigger self\u2010nucleic acid mediated activation of plasmacytoid DCs (pDCs) in psoriatic skin. Whether other cationic antimicrobial peptides exert similar activities is unknown. By analyzing heparin\u2010binding HPLC fractions of psoriatic scales, we found that human beta\u2010defensin (hBD)2, hBD3, and lysozyme are additional triggers of pDC activation in psoriatic skin lesions. Like LL37, hBD2, hBD3, and lysozyme are able to condense self\u2010DNA into particles that are endocytosed by pDCs, leading to activation of TLR9. In contrast, other antimicrobial peptides expressed in psoriatic skin including elafin, hBD1, and psoriasin (S100A7) did not show similar activities. hBD2, hBD3, and lysozyme were detected in psoriatic skin lesions in the vicinity of pDCs and found to cooperate with LL37 to induce high levels of IFN production by pDCs, suggesting their concerted role in the pathogenesis of psoriasis.<\/jats:p>","DOI":"10.1002\/eji.201344277","type":"journal-article","created":{"date-parts":[[2014,10,21]],"date-time":"2014-10-21T10:24:55Z","timestamp":1413887095000},"page":"203-213","source":"Crossref","is-referenced-by-count":142,"title":["Cationic antimicrobial peptides in psoriatic skin cooperate to break innate tolerance to self\u2010DNA"],"prefix":"10.1002","volume":"45","author":[{"given":"Roberto","family":"Lande","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospital of Lausanne CHUV  Lausanne Switzerland"},{"name":"Department of Infectious Parasitic and Immunomediated Diseases Istituto Superiore di Sanit\u00e0  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Chamilos","sequence":"additional","affiliation":[{"name":"Department of Immunology The University of Texas M. 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