{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T01:12:37Z","timestamp":1784769157833,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,5,12]],"date-time":"2014-05-12T00:00:00Z","timestamp":1399852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust, UK","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:p>Sarcoidosis is a multisystem granulomatous disorder characterized by marked T\u2010cell expansion of T helper 1 (Th1) cells. The cause of T\u2010cell overactivity is unknown. We hypothesized that interleukin\u201010 (IL\u201010) production by a yet undefined cell type might be defective, resulting in loss of regulation of T\u2010cell activity. Focusing on IL\u201010\u2010producing monocytes, we first showed that monocytes isolated from the peripheral blood of corticosteroid\u2010na\u00efve sarcoidosis patients (<jats:italic>n<\/jats:italic> = 51) produced less IL\u201010 compared to controls, and were less able to suppress T\u2010cell proliferation. In addition, monocytic IL\u201010 production correlated negatively with disease activity score. As invariant natural killer T (iNKT) cells are known to both interact with monocytes and be reduced in sarcoidosis patients, we then asked whether iNKT\u2010specific defects might be responsible for this reduced IL\u201010 production. We found that greater numbers of circulating iNKT cells was associated with higher IL\u201010 production. Moreover, iNKT cells enhanced monocytic IL\u201010 production in vitro. Defective IL\u201010 production and T\u2010cell suppression by sarcoidosis monocytes could be restored following their coculture with iNKT cells, in a CD1d\u2010 and cell contact\u2010dependent process. We suggest that reduced iNKT\u2010cell numbers in sarcoidosis may lead to impaired monocytic IL\u201010 production and unchecked T\u2010cell expansion in sarcoidosis. These findings provide fresh insight into the mechanism of sarcoidosis disease, and interaction between iNKT cells and monocytes.<\/jats:p>","DOI":"10.1002\/eji.201344284","type":"journal-article","created":{"date-parts":[[2014,4,10]],"date-time":"2014-04-10T18:11:46Z","timestamp":1397153506000},"page":"2165-2174","source":"Crossref","is-referenced-by-count":15,"title":["Abnormalities in iNKT cells are associated with impaired ability of monocytes to produce IL\u201010 and suppress T\u2010cell proliferation in sarcoidosis"],"prefix":"10.1002","volume":"44","author":[{"given":"Anjali","family":"Crawshaw","sequence":"first","affiliation":[{"name":"Weatherall Institute of Molecular Medicine University of Oxford  Oxford UK"},{"name":"Oxford Centre for Respiratory Medicine Churchill Hospital  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne R.","family":"Kendrick","sequence":"additional","affiliation":[{"name":"Weatherall Institute of Molecular Medicine University of Oxford  Oxford UK"},{"name":"Oxford Centre for Respiratory Medicine Churchill Hospital  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"McMichael","sequence":"additional","affiliation":[{"name":"Weatherall Institute of Molecular Medicine University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling\u2010Pei","family":"Ho","sequence":"additional","affiliation":[{"name":"Weatherall Institute of Molecular Medicine University of Oxford  Oxford UK"},{"name":"Oxford Centre for Respiratory Medicine Churchill Hospital  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.10.2104046"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2011.93"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.3.9906001"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.7.2005028"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200607-138MS"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.1.198-204.2002"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040429"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200905-0696OC"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2009.07.005"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/521030"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2005.01.009"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1519"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2010.09.002"},{"issue":"587","key":"e_1_2_7_15_1","first-page":"2074","article-title":"B\u2010regulatory cells in autoimmunity and immune mediated inflammation","volume":"201","author":"Vadasz Z.","journal-title":"FEBS Lett."},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.174.5.1209"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050648"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043588"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.5.9904078"},{"key":"e_1_2_7_20_1","doi-asserted-by":"crossref","first-page":"3673","DOI":"10.4049\/jimmunol.158.8.3673","article-title":"Contact with T cells modulates monocyte IL\u201010 production: Role of T\u2010cell membrane TNF\u2010alpha","volume":"158","author":"Parry S. L.","year":"1997","journal-title":"J. Immunol."},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.5.9904078"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2106"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.9.1361"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)71143-0"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2009.11.008"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxh020"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0411184"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103608"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-1759(97)00039-2"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2009.11.015"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0209059"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2013.6"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2711"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.03.004"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.2174\/156802610791561255"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201243185"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.1999.14d02.x"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.12.7350"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.201344284","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.201344284","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T04:42:27Z","timestamp":1696567347000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.201344284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,12]]},"references-count":37,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1002\/eji.201344284"],"URL":"https:\/\/doi.org\/10.1002\/eji.201344284","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,12]]}}}