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A higher tumor susceptibility is observed in WAS patients; whether this is a direct consequence of impaired immunosurveillance due to <jats:italic>WAS<\/jats:italic> deficiency in immune cells is, however, an open question. In this issue of the <jats:italic>European Journal of Immunology<\/jats:italic>, Catucci et al. [Eur. J. Immunol. 2014. 44: 1039\u20101045] shed light on the link between <jats:italic>Was<\/jats:italic> deficiency and immunosurveillance in a tumor\u2010prone mouse model and report a role for the impaired crosstalk between natural killer (NK) cells and dendritic cells (DCs) in mediating this process. The potential mechanisms involved in WASp regulation of NK\/DC\u2010mediated immunosurveillance are the focus of this Commentary.<\/jats:p>","DOI":"10.1002\/eji.201444514","type":"journal-article","created":{"date-parts":[[2014,3,19]],"date-time":"2014-03-19T08:07:19Z","timestamp":1395216439000},"page":"958-961","source":"Crossref","is-referenced-by-count":5,"title":["NK\/DC crosstalk in immunosurveillance: A broken relationship caused by WASP\u2010deficiency"],"prefix":"10.1002","volume":"44","author":[{"given":"Chiara","family":"Romagnani","sequence":"first","affiliation":[{"name":"Innate Immunity Deutsches Rheuma\u2010Forschungszentrum\u2013A Leibniz Institute  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Babic","sequence":"additional","affiliation":[{"name":"Innate Immunity Deutsches Rheuma\u2010Forschungszentrum\u2013A Leibniz Institute  Berlin Germany"},{"name":"Department of Histology and Embryology Faculty of Medicine, 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