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Here, we found that Foxp3 mutant scurfy mice had fewer B\u2010lineage cells and progenitors, including common lymphoid progenitors and lymphoid\u2010primed multipotent progenitors, but higher myeloid\u2010lineage cell numbers in BM compared with WT littermates. Homeostasis within the HSC compartment was also compromised with apparent expansion of long\u2010 and short\u2010term HSCs. This abnormality was due to the lack of Treg cells, but not to the Treg\u2010cell extrinsic functions of Foxp3 or cell\u2010autonomous defects. Among cytokines enriched in the BM of scurfy mice, IFN\u2010\u03b3 affected only B lymphopoiesis, but GM\u2010CSF, TNF, and IL\u20106 collectively promoted granulopoiesis at the expense of B lymphopoiesis. Neutralization of these three cytokines reversed the hematopoietic defects on early B\u2010cell progenitors in scurfy mice. Treg cells ensured B lymphopoiesis by reducing the production of these cytokines by effector T cells, but not by directly affecting B lymphopoiesis. These results suggest that Treg cells occupy an important niche in the BM to protect B\u2010lineage progenitor cells from excessive exposure to a lymphopoiesis\u2010regulating milieu.<\/jats:p>","DOI":"10.1002\/eji.201444532","type":"journal-article","created":{"date-parts":[[2014,10,28]],"date-time":"2014-10-28T09:43:11Z","timestamp":1414489391000},"page":"167-179","source":"Crossref","is-referenced-by-count":12,"title":["Foxp3<sup>+<\/sup> regulatory T cells ensure B lymphopoiesis by inhibiting the granulopoietic activity of effector T cells in mouse bone marrow"],"prefix":"10.1002","volume":"45","author":[{"given":"Sunghoon","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences Hanyang University Graduate School  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyungsoo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Research Center for Functional Cellulomics Seoul 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