{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:39:58Z","timestamp":1788871198264,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,4,14]],"date-time":"2014-04-14T00:00:00Z","timestamp":1397433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["WA 1552\/5-1"],"award-info":[{"award-number":["WA 1552\/5-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"name":"SAW program of the Leibniz Association"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2014,5]]},"abstract":"\n 2\n B<\/jats:styled-content>\n 4 (\n CD<\/jats:styled-content>\n 244), a member of the\n SLAM<\/jats:styled-content>\n \u2010related receptor family, has important immuno\u2010regulatory functions including coactivating the cytotoxicity and cytokine secretion of\n NK<\/jats:styled-content>\n cells. Immune modulation by 2\n B<\/jats:styled-content>\n 4 is dependent on the small intracellular signaling molecule\n SAP<\/jats:styled-content>\n . In patients suffering from\n X<\/jats:styled-content>\n \u2010linked lymphoproliferative disease (\n XLP<\/jats:styled-content>\n 1),\n SAP<\/jats:styled-content>\n is nonfunctional, not only abolishing the activating function of 2\n B<\/jats:styled-content>\n 4, but rendering this receptor inhibitory. In this issue of\n European Journal of Immunology<\/jats:italic>\n ,\n M<\/jats:styled-content>\n eazza et al. [Eur. J. Immunol. 2014. 44: 1526\u20131534.] demonstrate that 2\n B<\/jats:styled-content>\n 4\u2010mediated inhibition in\n NK<\/jats:styled-content>\n cells from\n XLP<\/jats:styled-content>\n 1 patients is selective. While the activation of\n NK<\/jats:styled-content>\n cells via ITAM\u2010based receptors is blocked by inhibitory 2\n B<\/jats:styled-content>\n 4,\n DNAM<\/jats:styled-content>\n \u20101, and\n NKG<\/jats:styled-content>\n 2\n D<\/jats:styled-content>\n \u2010dependent\n NK<\/jats:styled-content>\n \u2010cell activation is not affected by\n SAP<\/jats:styled-content>\n deficiency. These findings provide an important insight into the different defective\n NK<\/jats:styled-content>\n \u2010cell functions in\n XLP<\/jats:styled-content>\n 1 patients and demonstrate the differential integration of redundant receptor signaling pathways in\n NK<\/jats:styled-content>\n cells.\n <\/jats:p>","DOI":"10.1002\/eji.201444562","type":"journal-article","created":{"date-parts":[[2014,3,22]],"date-time":"2014-03-22T20:16:51Z","timestamp":1395519411000},"page":"1281-1284","source":"Crossref","is-referenced-by-count":6,"title":["What\n SAP<\/scp>\n \u2014 2\n B<\/scp>\n 4 sends mixed messages in the absence of\n SAP<\/scp>"],"prefix":"10.1002","volume":"44","author":[{"given":"Carsten","family":"Watzl","sequence":"first","affiliation":[{"name":"Leibniz Research Center for Working Environment and Human Factors Dortmund Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maren","family":"Claus","sequence":"additional","affiliation":[{"name":"Leibniz Research Center for Working Environment and Human Factors Dortmund Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,14]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.2741\/2735"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a002469"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.11.2083"},{"key":"e_1_2_4_5_1","doi-asserted-by":"crossref","first-page":"5809","DOI":"10.4049\/jimmunol.161.11.5809","article-title":"Identification of the 2B4 molecule as a counter\u2010receptor for CD48","volume":"161","author":"Latchman Y.","year":"1998","journal-title":"J. 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