{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T03:55:48Z","timestamp":1791172548259,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,12,4]],"date-time":"2014-12-04T00:00:00Z","timestamp":1417651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ligue contre le Cancer (Programme Equipe Labellis\u00c3\u00a9es and Comit\u00c3\u00a9 du Septentrion)"},{"name":"SIRIC OncoLille","award":["INCa-DGOS-Inserm 6041"],"award-info":[{"award-number":["INCa-DGOS-Inserm 6041"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p>Recent studies on acute myelogenous leukemia (AML) patients have revealed the existence of T\u2010cell immunodeficiencies, characterized by peripheral T lymphocytes that are unable to interact with blasts, reduced thymic emigrants and oligoclonal restricted repertoires. These observations suggest that there is a profound thymic dysregulation, which is difficult to study in AML patients. Using the C1498 AML mouse model, we demonstrated that leukemia development was associated with thymus atrophy, which was defined by abnormal organ weight and reduced cellularity. In addition, we observed a dramatic loss of peripheral CD4<jats:sup>+<\/jats:sup> and CD8<jats:sup>+<\/jats:sup> T\u2010cell numbers with increased frequencies of CD4<jats:sup>+<\/jats:sup>FoxP3<jats:sup>+<\/jats:sup> regulatory and activated\/memory T\u00a0cells. Investigating the mechanisms leading to this atrophy, we observed a significant accumulation of the monocyte chemoattractant protein 1 (MCP\u20101\/CCL2) in thymi of leukemic mice. Treatment of AML\u2010bearing animals with a blocking anti\u2010CCL2 antibody revealed a lower tumor burden, augmented antileukemic T\u2010cell responses, and improved survival rate compared to nontreated mice. These results were not observed when neutralization of CCL2 was performed in thymectomized mice. Altogether, we show that the CCL2 protein participates in thymic atrophy in AML mice, and this could have important implications for future immunotherapeutic strategies.<\/jats:p>","DOI":"10.1002\/eji.201444736","type":"journal-article","created":{"date-parts":[[2014,11,10]],"date-time":"2014-11-10T08:41:57Z","timestamp":1415608917000},"page":"396-406","source":"Crossref","is-referenced-by-count":23,"title":["Monocyte chemoattractant protein 1 (MCP\u20101\/CCL2) contributes to thymus atrophy in acute myeloid leukemia"],"prefix":"10.1002","volume":"45","author":[{"given":"Virginie","family":"Driss","sequence":"first","affiliation":[{"name":"Institut pour la Recherche sur le Cancer de Lille (IRCL) INSERM U.837  Lille Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Quesnel","sequence":"additional","affiliation":[{"name":"Institut pour la Recherche sur le Cancer de Lille (IRCL) INSERM U.837  Lille Cedex France"},{"name":"Service des Maladies du Sang Centre Hospitalier Universitaire de Lille  Lille France"},{"name":"Universit\u00e9 Lille Nord de France  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine","family":"Brinster","sequence":"additional","affiliation":[{"name":"Institut pour la Recherche sur le Cancer de Lille (IRCL) INSERM U.837  Lille Cedex France"},{"name":"Universit\u00e9 Lille Nord de France  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.13.3750"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-01-0163"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201444500"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-5769(03)00060-2"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-02-206946"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-3010"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2005.00537.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/10245330500226662"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-008-0621-3"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.10148"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-472X(03)00066-3"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-01-0064"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2012.08.006"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2006.12.012"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.8.5791"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-01-136895"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.54.2.227"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10568"},{"key":"e_1_2_7_20_1","doi-asserted-by":"crossref","first-page":"4300","DOI":"10.4049\/jimmunol.143.12.4300","article-title":"Thymic involution and thymocyte phenotypic alterations induced by murine mammary adenocarcinomas","volume":"143","author":"Fu Y.","year":"1989","journal-title":"J. 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