{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:12:28Z","timestamp":1789593148963,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,11,27]],"date-time":"2014-11-27T00:00:00Z","timestamp":1417046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Science and Education of Republic of Serbia","award":["ON175069, ON175103"],"award-info":[{"award-number":["ON175069, ON175103"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p>Galectin\u20103 (Gal\u20103), an endogenous lectin, exhibits pro\u2010 and anti\u2010inflammatory effects in various disease conditions. In order to explore the role of Gal\u20103 in NKT\u2010cell\u2010dependent pathology, we induced hepatitis in C57BL\/6 WT and Gal\u20103\u2010deficient mice by using specific ligand for NKT cells: \u03b1\u2010galactosylceramide, glycolipid Ag presented by CD1d. The injection of \u03b1\u2010galactosylceramide significantly enhanced expression of Gal\u20103 in liver NKT and dendritic cells (DCs). Genetic deletion or selective inhibition of Gal\u20103 (induced by Gal\u20103\u2010inhibitor TD139) abrogated the susceptibility to NKT\u2010cell\u2010dependent hepatitis. Blood levels of pro\u2010inflammatory cytokines (TNF\u2010\u03b1, IFN\u2010\u03b3, IL\u201012) and their production by liver DCs and NKT cells were also downregulated. Genetic deletion or selective inhibition of Gal\u20103 alleviated influx of inflammatory CD11c<jats:sup>+<\/jats:sup>CD11b<jats:sup>+<\/jats:sup> DCs in the liver and favored tolerogenic phenotype and IL\u201010 production of liver NKT and DCs. Deletion of Gal\u20103 attenuated the capacity of DCs to support liver damage in the passive transfer experiments and to produce pro\u2010inflammatory cytokines in vitro. Gal\u20103\u2010deficient DCs failed to optimally stimulate production of pro\u2010inflammatory cytokines in NKT cells, in vitro and in vivo. In conclusion, Gal\u20103 regulates the capacity of DCs to support NKT\u2010cell\u2010mediated liver injury, playing an important pro\u2010inflammatory role in acute liver injury.<\/jats:p>","DOI":"10.1002\/eji.201444849","type":"journal-article","created":{"date-parts":[[2014,10,31]],"date-time":"2014-10-31T10:16:01Z","timestamp":1414750561000},"page":"531-543","source":"Crossref","is-referenced-by-count":45,"title":["Gal\u20103 regulates the capacity of dendritic cells to promote NKT\u2010cell\u2010induced liver injury"],"prefix":"10.1002","volume":"45","author":[{"given":"Vladislav","family":"Volarevic","sequence":"first","affiliation":[{"name":"Centre for Molecular Medicine and Stem Cell Research Faculty of Medical Sciences University of Kragujevac  Kragujevac Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bojana Simovic","family":"Markovic","sequence":"additional","affiliation":[{"name":"Centre for Molecular Medicine and Stem Cell Research Faculty of Medical Sciences University of Kragujevac  Kragujevac Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanja","family":"Bojic","sequence":"additional","affiliation":[{"name":"Centre for Molecular Medicine and Stem Cell Research Faculty of Medical Sciences University of Kragujevac  Kragujevac Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Stojanovic","sequence":"additional","affiliation":[{"name":"Centre for Molecular Medicine and Stem Cell Research Faculty of Medical Sciences University of Kragujevac  Kragujevac Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Centre for Analysis and Synthesis Department of Chemistry Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakon","family":"Leffler","sequence":"additional","affiliation":[{"name":"Section MIG Department of Laboratory Medicine Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurdyal S.","family":"Besra","sequence":"additional","affiliation":[{"name":"School of Biosciences University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nebojsa","family":"Arsenijevic","sequence":"additional","affiliation":[{"name":"Centre for Molecular Medicine and Stem Cell Research Faculty of Medical Sciences University of Kragujevac  Kragujevac Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verica","family":"Paunovic","sequence":"additional","affiliation":[{"name":"Institute for Microbiology and Immunology School of Medicine University of Belgrade  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Trajkovic","sequence":"additional","affiliation":[{"name":"Institute for Microbiology and Immunology School of Medicine University of Belgrade  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miodrag L.","family":"Lukic","sequence":"additional","affiliation":[{"name":"Centre for Molecular Medicine and Stem Cell Research Faculty of Medical Sciences University of Kragujevac  Kragujevac Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201343381"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-306290"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.09.020"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25542"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-012-8286-6"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.6.2960"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201343866"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201242705"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200007)30:7<1919::AID-IMMU1919>3.0.CO;2-3"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115836"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.3.1540"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.276"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.10.7221"},{"key":"e_1_2_7_15_1","first-page":"38","article-title":"Regulatory T cells but not NKT I cells are modulated by a single low\u2010dose cyclophosphamide in a B cell lymphoma tumor\u2010model","volume":"34","author":"Rico M. 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