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At the first checkpoint, \u03bc heavy (\u03bcH) chains assemble with surrogate light (SL) chain into a precursor B\u2010cell receptor. In mice lacking SL chain, \u03bcH chain selection is impaired, and serum autoantibody levels are elevated. However, whether the development of autoantibody\u2010producing cells is due to an inability of the resultant B\u2010cell receptors to induce central and\/or peripheral B\u2010cell tolerance or other factors is unknown. Here, we show that receptor editing is defective, and that a higher proportion of BM immature B cells are prone to undergoing apoptosis. Furthermore, transitional B cells are also more prone to undergoing apoptosis, with a stronger selection pressure to enter the follicular B\u2010cell pool. Those that enter the marginal zone (MZ) B\u2010cell pool escape selection and survive, possibly due to the B\u2010lymphopenia and elevated levels of B\u2010cell activating factor. Moreover, the MZ B cells are responsible for the elevated IgM anti\u2010dsDNA antibody levels detected in these mice. Thus, the SL chain is required for central and peripheral B\u2010cell tolerance and inhibits anti\u2010DNA antibody production by MZ B cells.<\/jats:p>","DOI":"10.1002\/eji.201444917","type":"journal-article","created":{"date-parts":[[2014,12,27]],"date-time":"2014-12-27T13:46:44Z","timestamp":1419688004000},"page":"1228-1237","source":"Crossref","is-referenced-by-count":9,"title":["Surrogate light chain is required for central and peripheral B\u2010cell tolerance and inhibits anti\u2010DNA antibody production by marginal zone B cells"],"prefix":"10.1002","volume":"45","author":[{"given":"Weicheng","family":"Ren","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Inflammation Research University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ola","family":"Grimsholm","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Inflammation Research University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelina I.","family":"Bernardi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Inflammation Research University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"H\u00f6\u00f6k","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Inflammation Research University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Stern","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Inflammation Research University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Cavallini","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Inflammation Research University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inga\u2010Lill","family":"M\u00e5rtensson","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Inflammation Research University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03724"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/381751a0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1939"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.4049\/jimmunol.152.4.1970","article-title":"Deletion and editing of B cells that express antibodies to DNA","volume":"152","author":"Chen C.","year":"1994","journal-title":"J. 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