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Bcl\u20103 functions as a cofactor of p50\/NF\u2010\u03baB1 or p52\/NF\u2010\u03baB2 homodimers in nuclei, where it modulates NF\u2010\u03baB\u2010regulated transcription in a context\u2010dependent way. Bcl\u20103 has tumorigenic potential, is critical in host defense of pathogens, and has been reported to ameliorate or exacerbate inflammation, depending on disease model. However, cell\u2010specific functions of Bcl\u20103 remain largely unknown. Here, we explored the role of Bcl\u20103 in a contact hypersensitivity (CHS) mouse model, which depends on the interplay between keratinocytes and immune cells. Bcl\u20103\u2010deficient mice exhibited an exacerbated and prolonged CHS response to oxazolone. Increased inflammation correlated with higher production of chemokines CXCL2, CXCL9, and CXCL10, and consequently increased recruitment of neutrophils and CD8<jats:sup>+<\/jats:sup> T cells. BM chimera experiments indicated that the ability of Bcl\u20103 to reduce the CHS response depended on Bcl\u20103 activity in radioresistant cells. Specific ablation of Bcl\u20103 in keratinocytes resulted in increased production of CXCL9 and CXCL10 and sustained recruitment of specifically CD8<jats:sup>+<\/jats:sup> T cells. These findings identify Bcl\u20103 as a critical player during the later stage of the CHS reaction to limit inflammation via actions in radioresistant cells, including keratinocytes.<\/jats:p>","DOI":"10.1002\/eji.201444994","type":"journal-article","created":{"date-parts":[[2015,1,23]],"date-time":"2015-01-23T12:26:36Z","timestamp":1422015996000},"page":"1059-1068","source":"Crossref","is-referenced-by-count":11,"title":["The NF\u2010\u03baB regulator Bcl\u20103 modulates inflammation during contact hypersensitivity reactions in radioresistant cells"],"prefix":"10.1002","volume":"45","author":[{"given":"Ilaria","family":"Tassi","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Immunology National Institute of Allergy and Infectious Diseases, National Institutes of Health  Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nimisha","family":"Rikhi","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology National Institute of Allergy and Infectious Diseases, National Institutes of Health  Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estefania","family":"Claudio","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology National Institute of Allergy and Infectious Diseases, National Institutes of Health  Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongshan","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology National Institute of Allergy and Infectious Diseases, National Institutes of Health  Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanhu","family":"Tang","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology National Institute of Allergy and Infectious Diseases, National Institutes of Health  Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye\u2010lin","family":"Ha","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology National Institute of Allergy and Infectious Diseases, National Institutes of Health  Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun","family":"Saret","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology National Institute of Allergy and Infectious Diseases, National Institutes of Health  Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel H.","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Minnesota  Minneapolis MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Siebenlist","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology National Institute of Allergy and Infectious Diseases, National Institutes of Health  Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2011.02832.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.284"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.01.020"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1629"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90347-H"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3620"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-10-152"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.03.041"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80291-5"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI42596"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001331"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/db10-0480"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.07.017"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12119"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.49"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199911)29:11<3485::AID-IMMU3485>3.0.CO;2-B"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0304193"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830251103"},{"key":"e_1_2_6_20_1","first-page":"51","article-title":"Immunology of allergic contact dermatitis","volume":"19","author":"Toncic R. 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