{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:48:02Z","timestamp":1791251282043,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,3,20]],"date-time":"2015-03-20T00:00:00Z","timestamp":1426809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"SFB 650"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:p>\n                    The role of Th17 cells in the pathogenesis of autoantibody\u2010mediated diseases is unclear. Here, we assessed the contribution of Th17 cells to the pathogenesis of experimental autoimmune myasthenia gravis (EAMG), which is induced by repetitive immunizations with\n                    <jats:italic>Torpedo californica<\/jats:italic>\n                    acetylcholine receptor (tAChR). We show that a significant fraction of tAChR\u2010specific CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells is producing IL\u201017. IL\u201017\n                    <jats:sup>ko<\/jats:sup>\n                    mice developed fewer or no EAMG symptoms, although the frequencies of tAChR\u2010specific CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells secreting IL\u20102, IFN\u2010\u03b3, or IL\u201021, and the percentage of FoxP3\n                    <jats:sup>+<\/jats:sup>\n                    T\n                    <jats:sub>reg<\/jats:sub>\n                    cells were similar to WT mice. Even though the total anti\u2010tAChR antibody levels were equal, the complement fixating IgG2b subtype was reduced in IL\u201017\n                    <jats:sup>ko<\/jats:sup>\n                    as compared to WT mice. Most importantly, pathogenic anti\u2010murine AChR antibodies were significantly lower in IL\u201017\n                    <jats:sup>ko<\/jats:sup>\n                    mice. Furthermore, we confirmed the role of Th17 cells in EAMG pathogenesis by the reconstitution of TCR \u03b2\/\u03b4\n                    <jats:sup>ko<\/jats:sup>\n                    mice with WT or IL\u201017\n                    <jats:sup>ko<\/jats:sup>\n                    CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells. In conclusion, we show that the level of IgG2b and the loss of B\u2010cell tolerance, which results in pathogenic anti\u2010murine AChR\u2010specific antibodies, are dependent on IL\u201017 production by CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells. Thus, we describe here for the first time how Th17 cells are involved in the induction of classical antibody\u2010mediated autoimmunity.\n                  <\/jats:p>","DOI":"10.1002\/eji.201445064","type":"journal-article","created":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T22:42:59Z","timestamp":1423780979000},"page":"1339-1347","source":"Crossref","is-referenced-by-count":83,"title":["IL\u201017\u2010producing CD4\n                    <sup>+<\/sup>\n                    T cells contribute to the loss of B\u2010cell tolerance in experimental autoimmune myasthenia gravis"],"prefix":"10.1002","volume":"45","author":[{"given":"Hanne","family":"Schaffert","sequence":"first","affiliation":[{"name":"Department of Experimental Neurology Charit\u00e9\u2013University Medicine Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Pelz","sequence":"additional","affiliation":[{"name":"Department of Experimental Neurology Charit\u00e9\u2013University Medicine Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Saxena","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neuropsychology School for Mental Health and Neuroscience Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Losen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neuropsychology School for Mental Health and Neuroscience Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Meisel","sequence":"additional","affiliation":[{"name":"Department of Experimental Neurology Charit\u00e9\u2013University Medicine Berlin  Berlin Germany"},{"name":"NeuroCure Clinical Research Center (NCRC) Charit\u00e9\u2013University Medicine Berlin  Berlin Germany"},{"name":"Department of Neurology 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