{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:58:24Z","timestamp":1792036704285,"version":"4.4.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,3,19]],"date-time":"2015-03-19T00:00:00Z","timestamp":1426723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"DFG","award":["SFB 854"],"award-info":[{"award-number":["SFB 854"]}]},{"name":"DFG","award":["TP A05"],"award-info":[{"award-number":["TP A05"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:p>The deubiquitinating enzyme CYLD is an important tumor suppressor and inhibitor of immune responses. In contrast to full\u2010length CYLD, the immunological function of the naturally occurring short splice variant of CYLD (sCYLD) is insufficiently described. Previously, we showed that DCs, which lack full\u2010length CYLD but express sCYLD, exhibit augmented NF\u2010\u03baB and DC activation. To explore the function of sCYLD in infection, we investigated whether DC\u2010specific sCYLD regulates the pathogenesis of listeriosis. Upon <jats:italic>Listeria monocytogenes<\/jats:italic> infection of CD11c\u2010Cre Cyld<jats:sup>ex7\/8 fl\/fl<\/jats:sup> mice, infection of CD8\u03b1<jats:sup>+<\/jats:sup> DCs, which are crucial for the establishment of listeriosis in the spleen, was not affected. However, NF\u2010\u03baB activity of CD11c\u2010Cre Cyld<jats:sup>ex7\/8 fl\/fl<\/jats:sup> DCs was increased, while activation of ERK and p38 was normal. In addition, CD11c\u2010Cre Cyld<jats:sup>ex7\/8 fl\/fl<\/jats:sup> DCs produced more TNF, IL\u201010, and IL\u201012 upon infection, which led to enhanced stimulation of IFN\u2010\u03b3\u2010producing NK cells. In addition CD11c\u2010Cre Cyld<jats:sup>ex7\/8 fl\/fl<\/jats:sup> DCs presented <jats:italic>Listeria<\/jats:italic> Ag more efficiently to CD8<jats:sup>+<\/jats:sup> T\u00a0cells resulting in a stronger pathogen\u2010specific CD8<jats:sup>+<\/jats:sup> T\u2010cell proliferation and more IFN\u2010\u03b3 production. Collectively, the improved innate and adaptive immunity and survival during listeriosis identify the DC\u2010specific FL\u2010CYLD\/sCYLD balance as a potential target to modulate NK\u2010cell and Ag\u2010specific CD8<jats:sup>+<\/jats:sup> T\u2010cell responses.<\/jats:p>","DOI":"10.1002\/eji.201445116","type":"journal-article","created":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T10:08:13Z","timestamp":1423822093000},"page":"1366-1376","source":"Crossref","is-referenced-by-count":12,"title":["Protective dendritic cell responses against listeriosis induced by the short form of the deubiquitinating enzyme CYLD are inhibited by full\u2010length CYLD"],"prefix":"10.1002","volume":"45","author":[{"given":"Rebecca","family":"Wurm","sequence":"first","affiliation":[{"name":"Institute of Medical Microbiology and Hospital Hygiene Otto\u2010von\u2010Guericke University Magdeburg  Magdeburg 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Otto\u2010von\u2010Guericke University Magdeburg  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Blanchard","sequence":"additional","affiliation":[{"name":"Center for Pathophysiology of Toulouse\u2010Purpan INSERM U1043  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ari","family":"Waisman","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine University of Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans\u2010J\u00f6rg","family":"Schild","sequence":"additional","affiliation":[{"name":"Institute of Immunology University of Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Deckert","sequence":"additional","affiliation":[{"name":"Department of Neuropathology University Hospital Cologne  Cologne 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