{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:28:53Z","timestamp":1789594133075,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,5,6]],"date-time":"2015-05-06T00:00:00Z","timestamp":1430870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CAPES - Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"},{"name":"CNPq - Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"DOI":"10.13039\/501100004612","name":"FA - Funda\u00e7\u00e3o Arauc\u00e1ria","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004612","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:p>Although HLA\u2010A3 and A11 have been reported to be ligands for KIR3DL2, evidence for any in vivo relevance of this interaction is still missing. To explore the functional importance of <jats:italic>KIR3DL2<\/jats:italic> allelic variation, we analyzed the autoimmune disease pemphigus foliaceus, previously associated (lower risk) with activating <jats:italic>KIR<\/jats:italic> genes. <jats:italic>KIR3DL2*001<\/jats:italic> was increased in patients (odds ratio (OR) = 2.04; <jats:italic>p<\/jats:italic> = 0.007). The risk was higher for the presence of both <jats:italic>KIR3DL2*001<\/jats:italic> and HLA\u2010A3 or A11 (OR = 3.76, <jats:italic>p<\/jats:italic> = 0.013), providing the first evidence that HLA\u2010A3 and A11 may interact with KIR3DL2 in vivo. The nonsynonymous single nucleotide polymorphism <jats:italic>1190T<\/jats:italic> (<jats:italic>rs3745902<\/jats:italic>) was associated with protection (OR = 0.52, <jats:italic>p<\/jats:italic> = 0.018). This SNP results in a threonine\u2010to\u2010methionine substitution. Individuals who have methionine in this position exhibit a lower percentage of KIR3DL2\u2010positive natural killer (NK) cells and also lower intensity of KIR3DL2 on expressing natural killer cells; additionally, we show that the expression of KIR3DL2 is independent of other killer cell immunoglobulin\u2010like receptors. Pemphigus foliaceus is a very unique complex disease strongly associated with immune\u2010related genes. It is the only autoimmune disease known to be endemic, showing a strong correlation with environmental factors. Our data demonstrate that this relatively unknown autoimmune disease may facilitate understanding of the molecular mechanisms of KIR3DL2 ligand recognition.<\/jats:p>","DOI":"10.1002\/eji.201445324","type":"journal-article","created":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T10:17:47Z","timestamp":1428920267000},"page":"2052-2060","source":"Crossref","is-referenced-by-count":29,"title":["Pemphigus is associated with <i>KIR3DL2<\/i> expression levels and provides evidence that KIR3DL2 may bind HLA\u2010A3 and A11 in vivo"],"prefix":"10.1002","volume":"45","author":[{"given":"Danillo G.","family":"Augusto","sequence":"first","affiliation":[{"name":"Departamento de Gen\u00e9tica Universidade Federal do Paran\u00e1  Curitiba PR Brazil"},{"name":"Ragon Institute of MGH MIT and Harvard  Boston MA USA"},{"name":"Leidos Biomedical Research Cancer and Inflammation Program Laboratory for Experimental Immunology Frederick National Laboratory for Cancer Research  Frederick MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geraldine M.","family":"O'Connor","sequence":"additional","affiliation":[{"name":"Cancer and Inflammation Program Center for Cancer Research National Cancer Institute  Frederick MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara C.","family":"Lobo\u2010Alves","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica Universidade Federal do Paran\u00e1  Curitiba PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Bass","sequence":"additional","affiliation":[{"name":"Leidos Biomedical Research Cancer and Inflammation Program Laboratory for Experimental Immunology Frederick National Laboratory for Cancer Research  Frederick MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen P.","family":"Martin","sequence":"additional","affiliation":[{"name":"Leidos Biomedical Research Cancer and Inflammation Program Laboratory for Experimental Immunology Frederick National Laboratory for Cancer Research  Frederick MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Carrington","sequence":"additional","affiliation":[{"name":"Ragon Institute of MGH MIT and Harvard  Boston MA USA"},{"name":"Leidos Biomedical Research Cancer and Inflammation Program Laboratory for Experimental Immunology Frederick National Laboratory for Cancer Research  Frederick MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel W.","family":"McVicar","sequence":"additional","affiliation":[{"name":"Cancer and Inflammation Program Center for Cancer Research National Cancer Institute  Frederick MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luiza","family":"Petzl\u2010Erler","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica Universidade Federal do Paran\u00e1  Curitiba PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2003.11.016"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/0-387-24180-9_6"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2008.06.002"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003359900961"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002510000183"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.9.5118"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp879"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.20.092501.134942"},{"key":"e_1_2_8_10_1","first-page":"243","article-title":"ITAMs: immunoregulatory scaffolds that link immunoreceptors to their intracellular signaling pathways","volume":"5","author":"Isakov N.","year":"1998","journal-title":"Receptors Channels"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.17.1.875"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(96)80590-1"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200425089"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.9.6010"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056755"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-011-0565-1"},{"key":"e_1_2_8_17_1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/iji.12028","article-title":"16 thIHIW: population global distribution of killer immunoglobulin\u2010like receptor (KIR) and ligands","volume":"40","author":"Hollenbach J. 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