{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:52:16Z","timestamp":1792590736095,"version":"4.5.0"},"reference-count":47,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,8,6]],"date-time":"2015-08-06T00:00:00Z","timestamp":1438819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004385","name":"Universiteit Gent","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004385","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Belgian Science Policy - Interuniversity Attraction Pools (IAP)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>\n                    Plakophilin\u20103 (PKP3) is a member of the armadillo protein family, which is important in cell\u2212cell contacts and signaling during development and tumorigenesis. In conventional facilities, PKP3\u2010deficient mice (PKP3\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    ) develop spontaneous dermatitis, indicating a possible involvement of PKP3 in inflammatory responses. Here, we show that PKP3 deficiency sensitizes mice to irritant contact dermatitis induced by phorbol myristate acetate (PMA). This sensitization occurred in mice with PKP3 deficiency in the hematopoietic system (PKP3\n                    <jats:sup>\u2212\/\u2212hem<\/jats:sup>\n                    ), but not if the deficiency was specific to skin keratinocytes (PKP3\n                    <jats:sup>\u2212\/\u2212ker<\/jats:sup>\n                    ). In a model of dextran sulfate sodium induced colitis, ubiquitous PKP3 deletion, but not intestinal epithelial PKP3 deficiency (PKP3\n                    <jats:sup>\u2212\/\u2212IEC<\/jats:sup>\n                    ), impaired survival from disease. Interestingly, PKP3\n                    <jats:sup>\u2212\/\u2212hem<\/jats:sup>\n                    mice also displayed increased sensitivity to dextran sulfate sodium induced colitis. Finally, PKP3\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice were more sensitive to the lethality of lipopolysaccharide (LPS) injection than wild\u2010type (WT) mice, and this phenotype was associated with increased intestinal permeability. PKP3\n                    <jats:sup>\u2212\/\u2212IEC<\/jats:sup>\n                    mice did not reproduce the enhanced endotoxin reactivity of PKP3\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice, in contrast to PKP3\n                    <jats:sup>\u2212\/\u2212hem<\/jats:sup>\n                    mice. Finally,\n                    <jats:italic>in vitro<\/jats:italic>\n                    stimulation of WT neutrophils with LPS or PMA increased\n                    <jats:italic>Pkp3<\/jats:italic>\n                    expression.\n                  <\/jats:p>\n                  <jats:p>In conclusion, our data highlight a novel role for hematopoietic PKP3 in the regulation of both locally and systemically induced immune responses. Nonetheless, further research is needed to unravel the underlying mechanism.<\/jats:p>","DOI":"10.1002\/eji.201445440","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T18:47:38Z","timestamp":1436899658000},"page":"2898-2910","source":"Crossref","is-referenced-by-count":19,"title":["Hematopoietic plakophilin\u20103 regulates acute tissue\u2010specific and systemic inflammation in mice"],"prefix":"10.1002","volume":"45","author":[{"given":"Tatyana","family":"Sklyarova","sequence":"first","affiliation":[{"name":"Inflammation Research Center  VIB Ghent Belgium"},{"name":"Department of Biomedical Molecular Biology Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanda","family":"van Hengel","sequence":"additional","affiliation":[{"name":"Inflammation Research Center  VIB Ghent Belgium"},{"name":"Department of Biomedical Molecular Biology Ghent University  Ghent Belgium"},{"name":"Department of Basic Medical Sciences Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elien","family":"Van Wonterghem","sequence":"additional","affiliation":[{"name":"Inflammation Research Center  VIB Ghent Belgium"},{"name":"Department of Biomedical Molecular Biology Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Libert","sequence":"additional","affiliation":[{"name":"Inflammation Research Center  VIB Ghent Belgium"},{"name":"Department of Biomedical Molecular Biology Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frans","family":"van Roy","sequence":"additional","affiliation":[{"name":"Inflammation Research Center  VIB Ghent Belgium"},{"name":"Department of Biomedical Molecular Biology Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roosmarijn E.","family":"Vandenbroucke","sequence":"additional","affiliation":[{"name":"Inflammation Research Center  VIB Ghent Belgium"},{"name":"Department of Biomedical Molecular Biology Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.092890"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3608"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4292\/wjgpt.v4.i3.41","article-title":"Inflammatory bowel disease: an archetype disorder of outer environment sensor systems","volume":"4","author":"Actis G. 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