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An article by Br\u00fchl et\u00a0al. in this issue of the <jats:italic>European Journal of Immunology<\/jats:italic> [Eur. J. Immunol. 2015. 45: 705\u2013715] reveals a fundamentally distinct mechanism of silencing autoimmune B\u2010cell responses. Rather than B\u2010cell depletion, the authors use anti\u2010CD79b antibodies to induce B\u2010cell tolerance and suppress humoral immune responses against collagen to prevent the development of arthritis in mice. Here we highlight the differences in the mechanisms used by anti\u2010CD20 and anti\u2010CD79b Ab therapy and discuss why depletion of B\u00a0cells may not be required to treat autoimmune arthritis and other B\u2010cell\u2010associated pathologies.<\/jats:p>","DOI":"10.1002\/eji.201545464","type":"journal-article","created":{"date-parts":[[2015,1,31]],"date-time":"2015-01-31T10:11:20Z","timestamp":1422699080000},"page":"687-691","source":"Crossref","is-referenced-by-count":2,"title":["Rehabilitation or the death penalty: Autoimmune B\u00a0cells in the dock"],"prefix":"10.1002","volume":"45","author":[{"given":"Lekh N.","family":"Dahal","sequence":"first","affiliation":[{"name":"Antibody and Vaccine Group Cancer Sciences Unit Faculty of Medicine General Hospital University of Southampton  Southampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark S.","family":"Cragg","sequence":"additional","affiliation":[{"name":"Antibody and Vaccine Group Cancer Sciences Unit Faculty of Medicine General Hospital University of Southampton  Southampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,10]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201444971"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.098038"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2196"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90628-9"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032534"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035075"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.173"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200939578"},{"key":"e_1_2_4_10_1","doi-asserted-by":"crossref","first-page":"5178","DOI":"10.4049\/jimmunol.157.11.5178","article-title":"Autoantibodies to murine type II collagen in collagen\u2010induced arthritis: a comparison of susceptible and nonsusceptible strains","volume":"157","author":"Brand D. 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