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Besides its action as an oncoprotein, Bcl\u20103 has been shown to have both proinflammatory and anti\u2010inflammatory functions depending on the cell\u2010type affected. In this issue of the <jats:italic>European Journal of Immunology<\/jats:italic>, Tassi et\u00a0al. [Eur. J. Immunol. 2015. 45: 1059\u20131068] report that Bcl\u20103 inhibits the production of the proinflammatory chemokines CXCL9 and CXCL10 in keratinocytes, thereby restricting the influx of CD8<jats:sup>+<\/jats:sup> effector T cells in a mouse model of allergic contact dermatitis. In addition, mice with a global deficiency of Bcl\u20103 show enhanced ear swelling responses in the late phase of contact hypersensitivity responses. Besides keratinocytes, other radioresistant cell types appear to also utilize Bcl\u20103 to dampen the inflammatory response. This Commentary will discuss the evidence supporting Bcl\u20103 as a critical player in limiting inflammation during the later stages of contact hypersensitivity.<\/jats:p>","DOI":"10.1002\/eji.201545524","type":"journal-article","created":{"date-parts":[[2015,2,24]],"date-time":"2015-02-24T10:25:53Z","timestamp":1424773553000},"page":"971-974","source":"Crossref","is-referenced-by-count":1,"title":["Bcl\u20103 puts the brakes on contact hypersensitivity"],"prefix":"10.1002","volume":"45","author":[{"given":"Heike","family":"Weighardt","sequence":"first","affiliation":[{"name":"Immunology and Environment Life and Medical Sciences (LIMES) Institute University of Bonn  Bonn Germany"},{"name":"IUF Leibniz Research Institute for Environmental Medicine  D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irmgard","family":"F\u00f6rster","sequence":"additional","affiliation":[{"name":"Immunology and Environment Life and Medical Sciences (LIMES) Institute University of Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,20]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.284"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02652.x"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3150"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201444994"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1478-811X-11-23"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.183434.111"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/db10-0480"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12119"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90401-B"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjt020"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001331"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.07.017"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.09.017"},{"key":"e_1_2_4_15_1","first-page":"203","article-title":"Chemokine networks in inflammatory skin diseases","volume":"14","author":"Pastore S.","year":"2004","journal-title":"Eur. 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