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Moreover, selective inhibition of the immunoproteasome subunit LMP7 ameliorated symptoms of autoimmune diseases including CD4<jats:sup>+<\/jats:sup> T\u2010cell mediated EAE. In this study, we show that LMP7 also plays a crucial role in the pathogenesis of lymphocytic choriomeningitis virus (LCMV)\u2010induced meningitis mediated by CTLs. Mice lacking functional LMP7 display delayed and reduced clinical signs of disease accompanied by a strongly decreased inflammatory infiltration into the brain. Interestingly, we found that selective inhibition and genetic deficiency of LMP7 affect the pathogenesis of LCMV\u2010induced meningitis in a distinct manner. Our findings support the important role of LMP7 in inflammatory disorders and suggest immunoproteasome inhibition as a novel strategy against inflammation\u2010induced neuropathology in the CNS.<\/jats:p>","DOI":"10.1002\/eji.201545578","type":"journal-article","created":{"date-parts":[[2015,10,14]],"date-time":"2015-10-14T09:01:24Z","timestamp":1444813284000},"page":"104-113","source":"Crossref","is-referenced-by-count":36,"title":["Inhibition and deficiency of the immunoproteasome subunit LMP7 attenuates LCMV\u2010induced meningitis"],"prefix":"10.1002","volume":"46","author":[{"given":"Sarah","family":"Mundt","sequence":"first","affiliation":[{"name":"Division of Immunology Department of Biology University of Konstanz  Konstanz Germany"},{"name":"Konstanz Research School Chemical Biology (KoRS\u2010CB) University of Konstanz  Konstanz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Britta","family":"Engelhardt","sequence":"additional","affiliation":[{"name":"Theodor Kocher Institute University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J.","family":"Kirk","sequence":"additional","affiliation":[{"name":"Onyx Pharmaceuticals South San Francisco  CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Groettrup","sequence":"additional","affiliation":[{"name":"Division of Immunology Department of Biology University of Konstanz  Konstanz Germany"},{"name":"Biotechnology Institute Thurgau at the University of Konstanz (BITg)  Kreuzlingen Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Basler","sequence":"additional","affiliation":[{"name":"Division of Immunology Department of Biology University of Konstanz  Konstanz Germany"},{"name":"Biotechnology Institute Thurgau at the University of Konstanz (BITg)  Kreuzlingen Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.12.030"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.1.1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.9.4500"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2687"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201040620"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1978"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201183"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903182"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2012.11.004"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2741\/3021"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(87)90260-7"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0167-5699(90)90019-6","article-title":"Dissection of an inflammatory process induced by CD8+ T cells","volume":"11","author":"Doherty P. 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