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Postulating that dendritic cells (DCs) participated in the suppression of inflammation and seeking to move beyond the use of helminths per se, we tested the ability of <jats:italic>Hymenolepis diminuta<\/jats:italic> antigen\u2010pulsed DCs to suppress colitis as a novel cell\u2010based immunotherapy. Bone marrow derived DCs pulsed with <jats:italic>H. diminuta<\/jats:italic> antigen (HD\u2010DCs), or PBS\u2010, BSA\u2010, or LPS\u2010DCs as controls, were transferred into wild\u2010type (WT), interleukin\u201010 (IL\u201010) knock\u2010out (KO), and RAG\u20101 KO mice, and the impact on dinitrobenzene sulphonic acid (DNBS)\u2010induced colitis and splenic cytokine production assessed 72 h later. Mice receiving HD\u2010DCs were significantly protected from DNBS\u2010induced colitis and of the experimental groups only these mice displayed increased Th2 cytokines and IL\u201010 production. Adoptive transfer of HD\u2010DCs protected neither RAG\u20101 nor IL\u201010 KO mice from DNBS\u2010colitis. Furthermore, the transfer of CD4<jats:sup>+<\/jats:sup> splenocytes from recipients of HD\u2010DCs protected na\u00efve mice against DNBS\u2010colitis, in an IL\u201010 dependent manner. Thus, HD\u2010DCs are a novel anti\u2010colitic immunotherapy that can educate anti\u2010colitic CD4<jats:sup>+<\/jats:sup> T cells: mechanistically, the anti\u2010colitic effect of HD\u2010DCs requires that the host has an adaptive immune response and the ability to mobilize IL\u201010.<\/jats:p>","DOI":"10.1002\/eji.201545579","type":"journal-article","created":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T17:34:36Z","timestamp":1441215276000},"page":"3126-3139","source":"Crossref","is-referenced-by-count":39,"title":["Adoptive transfer of helminth antigen\u2010pulsed dendritic cells protects against the development of experimental colitis in mice"],"prefix":"10.1002","volume":"45","author":[{"given":"Chelsea E.","family":"Matisz","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology Gastrointestinal Research Group and Inflammation Research Network Calvin Joan and Phoebe Snyder Institute for Chronic Diseases Cumming School of Medicine University of 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