{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:18:54Z","timestamp":1791839934504,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,7,28]],"date-time":"2015-07-28T00:00:00Z","timestamp":1438041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH","award":["R01 AI093553"],"award-info":[{"award-number":["R01 AI093553"]}]},{"name":"Wellcome Trust"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p>Chromoblastomycosis is a chronic skin infection caused by the pigmented saprophytic mould <jats:italic>Fonsecaea pedrosoi<\/jats:italic>. Chronicity of infection can be broken by a coordinated innate recognition of the spores by pattern recognition receptors. While Mincle signaling via the Syk\/Card9 pathway is required for fungal recognition by host cells, it is not sufficient for host control. Exogenously applied TLR agonists are necessary to promote the induction of proinflammatory cytokines and clearance of infection in vivo. Here, we investigated whether costimulation by TLR agonists fosters the development of adaptive immune responses, by examining the development of fungus\u2010specific T\u00a0cells. Subcutaneous infection of mice with <jats:italic>F. pedrosoi<\/jats:italic> spores induced the activation, expansion, and differentiation of Ag\u2010specific CD4<jats:sup>+<\/jats:sup> T\u00a0cells but TLR costimulation did not further augment these T\u2010cell responses. The Dectin\u20102\/FcR\u03b3\/Card9 signaling pathway promoted the differentiation of fungus\u2010specific CD4<jats:sup>+<\/jats:sup> T\u00a0cells into Th17 cells, whereas Mincle inhibited the development of this T\u2010helper subset in infected mice. These results indicate differential roles for Dectin\u20102 and Mincle in the generation of adaptive immune responses to <jats:italic>F. pedrosoi<\/jats:italic> infection.<\/jats:p>","DOI":"10.1002\/eji.201545591","type":"journal-article","created":{"date-parts":[[2015,7,3]],"date-time":"2015-07-03T15:58:59Z","timestamp":1435939139000},"page":"2542-2552","source":"Crossref","is-referenced-by-count":62,"title":["<i>Fonsecaea pedrosoi<\/i>\u2010induced Th17\u2010cell differentiation in mice is fostered by Dectin\u20102 and suppressed by Mincle recognition"],"prefix":"10.1002","volume":"45","author":[{"given":"Marcel","family":"W\u00fcthrich","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Wisconsin School of Medicine and Public Health University of Wisconsin\u2010Madison  WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huafeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Wisconsin School of Medicine and Public Health University of Wisconsin\u2010Madison  WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Wisconsin School of Medicine and Public Health University of Wisconsin\u2010Madison  WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tassanee","family":"Lerksuthirat","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Wisconsin School of Medicine and Public Health University of Wisconsin\u2010Madison  WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Hardison","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Wisconsin School of Medicine and Public Health University of Wisconsin\u2010Madison  WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon D.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Wisconsin School of Medicine and Public Health University of Wisconsin\u2010Madison  WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Wisconsin School of Medicine and Public Health University of Wisconsin\u2010Madison  WI USA"},{"name":"Department of Medical Microbiology and Immunology University of Wisconsin School of Medicine and Public Health University of Wisconsin\u2010Madison  WI USA"},{"name":"Aberdeen Fungal Group Institute of Medical Sciences University of Aberdeen  Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/13693780802538001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2009.03415.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2007.00077.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1179\/joc.2003.15.Supplement-2.36"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.1998.00335.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1997.00085.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.qco.0000216625.28692.67"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2011.04.005"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu168"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2006.01846.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2015.02.009"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"651","DOI":"10.4269\/ajtmh.1989.40.651","article-title":"Experimental murine chromomycosis mimicking chronic progressive human disease","volume":"40","author":"Ahrens J.","year":"1989","journal-title":"Am. 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