{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:42:37Z","timestamp":1786977757835,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,9,21]],"date-time":"2015-09-21T00:00:00Z","timestamp":1442793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:p>\n                    Infection of mice with\n                    <jats:italic>Listeria monocytogenes<\/jats:italic>\n                    results in a strong T\u2010cell response that is critical for an efficient defense. Here, we demonstrate that the adapter protein SLy1 (SH3\u2010domain protein expressed in Lymphocytes 1) is essential for the generation of a fully functional T\u2010cell response. The lack of SLy1 leads to reduced survival rates of infected mice. The increased susceptibility of SLy1 knock\u2010out (KO) mice was caused by reduced proliferation of differentiated T cells. Ex vivo analyses of isolated SLy1 KO T cells displayed a dysregulation of Forkhead box protein O1 shuttling after TCR signaling, which resulted in an increased expression of cell cycle inhibiting genes, and therefore, reduced expansion of the T\u2010cell population. Forkhead box protein O1 shuttles to the cytoplasm after phosphorylation in a protein complex including 14\u20103\u20103 proteins. Interestingly, we observed a similar regulation for the adapter protein SLy1, where TCR stimulation results in SLy1 phosphorylation and SLy1 export to the cytoplasm. Moreover, immunoprecipitation analyses revealed a binding of SLy1 to 14\u20103\u20103 proteins. Altogether, this study describes SLy1 as an immunoregulatory protein, which is involved in the generation of adaptive immune responses during\n                    <jats:italic>L. monocytogenes<\/jats:italic>\n                    infection, and provides a model of how SLy1 regulates T\u2010cell proliferation.\n                  <\/jats:p>","DOI":"10.1002\/eji.201545609","type":"journal-article","created":{"date-parts":[[2015,8,26]],"date-time":"2015-08-26T03:23:26Z","timestamp":1440559406000},"page":"3087-3097","source":"Crossref","is-referenced-by-count":19,"title":["SLy1 regulates T\u2010cell proliferation during\n                    <i>Listeria monocytogenes<\/i>\n                    infection in a Foxo1\u2010dependent manner"],"prefix":"10.1002","volume":"45","author":[{"given":"Daniel","family":"Sch\u00e4ll","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Experimental Therapy Institute of Experimental and Clinical Pharmacology and Toxicology Eberhard Karls University Hospitals and Clinics Interfaculty Center of Pharmacogenomics and Drug Research University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fee","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Experimental Therapy Institute of Experimental and Clinical Pharmacology and Toxicology Eberhard Karls University Hospitals and Clinics Interfaculty Center of Pharmacogenomics and Drug Research University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Reis","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology and Hospital Hygiene Heinrich Heine University  D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Brandt","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology and Hospital Hygiene Heinrich Heine University  D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Beer\u2010Hammer","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Experimental Therapy Institute of Experimental and Clinical Pharmacology and Toxicology Eberhard Karls University Hospitals and Clinics Interfaculty Center of Pharmacogenomics and Drug Research University of T\u00fcbingen  T\u00fcbingen Germany"},{"name":"Institute of Medical Microbiology and Hospital Hygiene Heinrich Heine University  D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.59.9.2892-2900.1991"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.61.12.5090-5096.1993"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(97)80156-2"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/11.3.325"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90134-C"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(95)90163-9"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"5297","DOI":"10.4049\/jimmunol.158.11.5297","article-title":"Impaired macrophage listericidal and cytokine activities are responsible for the rapid death of Listeria monocytogenes\u2010infected IFN\u2010gamma receptor\u2010deficient mice","volume":"158","author":"Dai W. 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