{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:14:15Z","timestamp":1761920055451},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T00:00:00Z","timestamp":1446768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>The genus leishmania comprises different protozoan parasites which are causative agents of muco\u2010cutaneous and systemic, potentially lethal diseases. After infection with the species <jats:italic>Leishmania major<\/jats:italic>, resistant mice expand Th1 cells which stimulate macrophages for Leishmania destruction. In contrast, susceptible mice generate Th2 cells which deactivate macrophages, leading to systemic spread of the pathogens. Th\u2010cell differentiation is determined within the first days, and Th2 cell differentiation requires IL\u20104, whereby the initial IL\u20104 source is often unknown. Mast cells are potential sources of IL\u20104, and hence their role in murine leishmaniasis has previously been studied in mast cell\u2010deficient Kit mutant mice, although these mice display immunological phenotypes beyond mast cell deficiency. We therefore readdressed this question by infecting Kit\u2010independent mast cell\u2010deficient mice that are Th1 (C57BL\/6 <jats:italic>Cpa<\/jats:italic><jats:sup><jats:italic>Cre<\/jats:italic><\/jats:sup>) or Th2 (BALB\/c <jats:italic>Cpa<jats:sup>Cre<\/jats:sup><\/jats:italic>) prone with <jats:italic>L. major<\/jats:italic>. Using different parasite doses and intra\u2010 or subcutaneous infection routes, the results demonstrate no role of mast cells on lesion size development, parasite load, immune cell phenotypes expanding in draining lymph nodes, and cytokine production during murine cutaneous leishmaniasis. Thus, other cell types such as ILCs or T cells have to be considered as primary source of Th2\u2010driving IL\u20104.<\/jats:p>","DOI":"10.1002\/eji.201545613","type":"journal-article","created":{"date-parts":[[2015,10,9]],"date-time":"2015-10-09T09:08:41Z","timestamp":1444381721000},"page":"114-121","source":"Crossref","is-referenced-by-count":23,"title":["Mast cells have no impact on cutaneous leishmaniasis severity and related Th2 differentiation in resistant and susceptible mice"],"prefix":"10.1002","volume":"46","author":[{"given":"Christoph","family":"Paul","sequence":"first","affiliation":[{"name":"Institute for Medical Microbiology Hospital Hygiene Philipps University Marburg  Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svenja","family":"Wolff","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology Hospital Hygiene Philipps University Marburg  Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thea","family":"Zapf","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology Hospital Hygiene Philipps University Marburg  Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hartmann","family":"Raifer","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology Hospital Hygiene Philipps University Marburg  Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thorsten B.","family":"Feyerabend","sequence":"additional","affiliation":[{"name":"Division of Cellular Immunology German Cancer Research Center  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadine","family":"Bollig","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology Hospital Hygiene Philipps University Marburg  Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e4rbel","family":"Camara","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology Hospital Hygiene Philipps University Marburg  Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Trier","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology Hospital Hygiene Philipps University Marburg  Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"Schleicher","sequence":"additional","affiliation":[{"name":"Institute for Clinical Microbiology Immunology and Hygiene Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans\u2010Reimer","family":"Rodewald","sequence":"additional","affiliation":[{"name":"Division of Cellular Immunology German Cancer Research Center  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Lohoff","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology Hospital Hygiene Philipps University Marburg  Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12032"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.07.040189.001045"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.179.4.1349"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90339-4"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1556\/EuJMI.3.2013.3.1"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.13.040195.001055"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000023900"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002282"},{"key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1128\/iai.61.5.2242-2244.1993","article-title":"Cutaneous leishmaniasis in mast cell\u2010deficient W\/Wv mice","volume":"61","author":"Katakura K.","year":"1993","journal-title":"Infect. 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