{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T02:39:00Z","timestamp":1789353540687,"version":"build-2803163510"},"reference-count":58,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,7,6]],"date-time":"2015-07-06T00:00:00Z","timestamp":1436140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003006","name":"ETH Zurich","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003006","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001660","name":"Ernst-Schering Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001660","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p>Chronic skin inflammation resulting from a defective epidermal barrier is a hallmark of atopic dermatitis (AD). We previously demonstrated that mice lacking FGF receptors 1 and 2 in keratinocytes (K5\u2010R1\/R2 mice) develop an AD\u2010like chronic dermatitis as a result of an impaired epidermal barrier. Here, we show that \u03b3\u03b4 T cells, which rapidly respond to various insults, accumulate in the epidermis of K5\u2010R1\/R2 mice before the development of histological abnormalities. Their number and activation further increase as the phenotype progresses, most likely as a consequence of increased expression of Il\u20102 and Il\u20107 and the stress\u2010induced proteins Rae\u20101, H60c, Mult1, PlexinB2, and Skint1. To determine the role of \u03b3\u03b4 T cells in the skin phenotype, we generated quadruple mutant K5\u2010R1\/\u2010R2 mice lacking \u03b3\u03b4 T cells. Surprisingly, loss of \u03b3\u03b4 T cells did not or only marginally affect keratinocyte proliferation, epidermal thickness, epidermal barrier function, and accumulation and activation of different immune cells in the skin of K5\u2010R1\/R2 mice, possibly due to partial compensation by \u03b1\u03b2 T cells. These results demonstrate that \u03b3\u03b4 T cells do not contribute to the development or maintenance of chronic inflammation in response to a defect in the epidermal barrier.<\/jats:p>","DOI":"10.1002\/eji.201545675","type":"journal-article","created":{"date-parts":[[2015,6,17]],"date-time":"2015-06-17T09:50:50Z","timestamp":1434534650000},"page":"2517-2528","source":"Crossref","is-referenced-by-count":15,"title":["Accumulation and activation of epidermal \u03b3\u03b4 T cells in a mouse model of chronic dermatitis is not required for the inflammatory phenotype"],"prefix":"10.1002","volume":"45","author":[{"given":"Jitka","family":"Sulcova","sequence":"first","affiliation":[{"name":"Department of Biology Institute of Molecular Health Sciences ETH Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Maddaluno","sequence":"additional","affiliation":[{"name":"Department of Biology Institute of Molecular Health Sciences ETH Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Biology Institute of Molecular Health Sciences ETH Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Werner","sequence":"additional","affiliation":[{"name":"Department of Biology Institute of Molecular Health Sciences ETH Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2008.00786.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2741\/4225"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200910126"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2015.02.005"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.09.031"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01593.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2455"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2781"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700003"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2622"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.44.12.1012"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12275516"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20081787"},{"key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"5392","DOI":"10.4049\/jimmunol.152.11.5392","article-title":"Unique antigen recognition by a herpesvirus\u2010specific TCR\u2010gamma delta cell","volume":"152","author":"Sciammas R.","year":"1994","journal-title":"J. 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