{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:06:23Z","timestamp":1791421583898,"version":"4.3.3"},"reference-count":52,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,8,28]],"date-time":"2015-08-28T00:00:00Z","timestamp":1440720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:p>Recent studies have revealed IL\u201033 as a key factor in promoting antiviral T\u2010cell responses. However, it is less clear as to how IL\u201033 regulates innate immunity. In this study, we infected wild\u2010type (WT) and IL\u201033<jats:sup>\u2212\/\u2212<\/jats:sup> mice with lymphocytic choriomeningitis virus and demonstrated an essential role of infection\u2010induced IL\u201033 expression for robust innate IFN\u2010\u03b3 production in the liver. We first show that IL\u201033 deficiency resulted in a marked reduction in the number of IFN\u2010\u03b3<jats:sup>+<\/jats:sup> \u03b3\u03b4\u00a0T and NK cells, but an increase in that of IL\u201017<jats:sup>+<\/jats:sup> \u03b3\u03b4\u00a0T cells at 16 h postinfection. Recombinant IL\u201033 (rIL\u201033) treatment could reverse such deficiency via increasing IFN\u2010\u03b3\u2010producing \u03b3\u03b4\u00a0T and NK cells, and inhibiting IL\u201017<jats:sup>+<\/jats:sup> \u03b3\u03b4\u00a0T cells. We also found that rIL\u201033\u2010induced type 2 innate lymphoid cells were not involved in T\u2010cell responses and liver injury, since the adoptive transfer of type 2 innate lymphoid cells neither affected the IFN\u2010\u03b3 and TNF\u2010\u03b1 production in T cells, nor liver transferase levels in lymphocytic choriomeningitis virus infected mice. Interestingly, we found that while IL\u201033 was not required for costimulatory molecule expression, it was critical for DC proliferation and cytokine production. Together, this study highlights an essential role of IL\u201033 in regulating innate IFN\u2010\u03b3\u2010production and DC function during viral hepatitis.<\/jats:p>","DOI":"10.1002\/eji.201545696","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:40:36Z","timestamp":1438944036000},"page":"3052-3063","source":"Crossref","is-referenced-by-count":34,"title":["IL\u201033 promotes innate IFN\u2010\u03b3 production and modulates dendritic cell response in LCMV\u2010induced hepatitis in mice"],"prefix":"10.1002","volume":"45","author":[{"given":"Yuejin","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology Institute for Human Infections and Immunity University of Texas Medical Branch  Galveston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuliang","family":"Jie","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Institute for Human Infections and Immunity University of Texas Medical Branch  Galveston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifei","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Institute for Human Infections and Immunity University of Texas Medical Branch  Galveston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panpan","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Institute for Human Infections and Immunity University of Texas Medical Branch  Galveston TX USA"},{"name":"Department of Infectious Diseases Key Laboratory of Viral Hepatitis of Hunan Xiangya Hospital Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Institute for Human Infections and Immunity University of Texas Medical Branch  Galveston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zakari","family":"Kwota","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Institute for Human Infections and Immunity University of Texas Medical Branch  Galveston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Salvato","sequence":"additional","affiliation":[{"name":"Institute of Human Virology University of Maryland School of Medicine  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene","family":"de Waal Malefyt","sequence":"additional","affiliation":[{"name":"Department of Immunology Merck Research Laboratories  Palo Alto CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Soong","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Institute for Human Infections and Immunity University of Texas Medical Branch  Galveston TX USA"},{"name":"Department of Pathology Institute for Human Infections and Immunity University of Texas Medical Branch  Galveston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaren","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Institute for Human Infections and Immunity University of Texas Medical Branch  Galveston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/smim.1998.0136"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07106"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1372"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.09.015"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1003059107"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1215418"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300117"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2781"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.08.006"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032712-100001"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.7.3920"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118843"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1301888"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2131"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25893"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201970"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1717"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901584"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1204327109"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1845"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021910"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2011.0109"},{"key":"e_1_2_7_24_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/819636","article-title":"Serum IL\u201033 levels are associated with liver damage in patients with chronic hepatitis C","volume":"2012","author":"Wang J.","year":"2012","journal-title":"Mediat. Inflamm."},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1418549112"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003599"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.5.2524"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2010.00663.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200259"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200838575"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1500424"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026780"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10624"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201141947"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.01.011"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1303281"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003073"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00116"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3365"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1246"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2013.07.006"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1183021"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1203543109"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxl007"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0902745106"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.07.008"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201041033"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200939472"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxr006"},{"key":"e_1_2_7_50_1","first-page":"1","article-title":"Lymphocytic choriomeningitis virus (LCMV): propagation, quantitation, and storage","volume":"15","author":"Welsh R. M.","year":"2008","journal-title":"Curr. Protoc. Microbiol."},{"key":"e_1_2_7_51_1","first-page":"1","article-title":"The use of carboxyfluorescein diacetate succinimidyl ester (CFSE) to monitor lymphocyte proliferation","volume":"44","author":"Quah B. J.","year":"2010","journal-title":"J. Vis. Exp."},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.11.7537"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08900"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.201545696","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.201545696","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T04:19:00Z","timestamp":1696565940000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.201545696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,28]]},"references-count":52,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1002\/eji.201545696"],"URL":"https:\/\/doi.org\/10.1002\/eji.201545696","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,28]]}}}