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IL\u201037 can be elevated in humans with inflammatory and autoimmune diseases where it likely functions to limit inflammation. Transgenic mice expressing human IL\u201037 (\n                    <jats:italic>IL37<\/jats:italic>\n                    \u2010tg) exhibit less severe inflammation in models of endotoxin shock, colitis, myocardial infarction, lung, and spinal cord injury.\n                    <jats:italic>IL37<\/jats:italic>\n                    \u2010tg mice have reduced antigen\u2010specific responses and dendritic cells (DCs) from these mice exhibit characteristics of tolerogenic DCs. Compared to aging wild\u2010type (WT) mice, aging\n                    <jats:italic>IL37<\/jats:italic>\n                    \u2010tg mice are protected against B\u2010cell leukemogenesis and heart failure. Treatment of WT mice with recombinant human IL\u201037 has been shown to be protective in several models of inflammation and injury. IL\u201037 binds to the IL\u201018 receptor but then recruits the orphan IL\u20101R8 (formerly TIR8 or SIGIRR) in order to function as an inhibitor. Here, we review the discovery of IL\u201037, its production, release, and mechanisms by which IL\u201037 reduces inflammation and suppresses immune responses. The data reviewed here suggest a therapeutic potential for IL\u201037.\n                  <\/jats:p>","DOI":"10.1002\/eji.201545828","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T14:42:40Z","timestamp":1460299360000},"page":"1067-1081","source":"Crossref","is-referenced-by-count":202,"title":["Suppression of innate inflammation and immunity by interleukin\u201037"],"prefix":"10.1002","volume":"46","author":[{"given":"Charles A.","family":"Dinarello","sequence":"first","affiliation":[{"name":"University of Colorado Denver  Aurora CO USA"},{"name":"Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Nold\u2010Petry","sequence":"additional","affiliation":[{"name":"Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Nold","sequence":"additional","affiliation":[{"name":"Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Fujita","sequence":"additional","affiliation":[{"name":"University of Colorado Denver  Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzhao","family":"Li","sequence":"additional","affiliation":[{"name":"University of Colorado Denver  Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soohyun","family":"Kim","sequence":"additional","affiliation":[{"name":"University of Colorado Denver  Aurora CO USA"},{"name":"Konkuk University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Bufler","sequence":"additional","affiliation":[{"name":"Ludwig\u2010Maximilian\u2010University  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,6]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1944"},{"key":"e_1_2_14_3_1","article-title":"IL\u201037 inhibits the production of pro\u2010inflammatory cytokines in MSU crystal\u2010induced inflammatory response","author":"Zeng M.","year":"2015","journal-title":"Clin. 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