{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T11:38:40Z","timestamp":1710416320615},"reference-count":56,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T00:00:00Z","timestamp":1443398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Canadian Institutes of Health Research (CIHR) and the Arthritis Society"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:p>Protective immunity to the pathogen <jats:italic>Chlamydia<\/jats:italic> is dependent on a robust IFN\u2010\u03b3 response generated by innate and adaptive lymphocytes. Here we assess the role of the macrophage in orchestrating a protective response in vivo to the murine pathogen, <jats:italic>Chlamydia muridarum<\/jats:italic>. During acute pulmonary and peritoneal infection, resident macrophages in both sites are infected with <jats:italic>C. muridarum<\/jats:italic> and adopt an inflammatory phenotype. In the lung, this activation is restricted to interstitial macrophages, which harbor higher levels of <jats:italic>C. muridarum 16sRNA<\/jats:italic> than alveolar macrophages. We examined innate and adaptive lymphocyte activation in the peritoneal cavity with macrophage depletion and with adoptive transfer of infected macrophages. These experiments demonstrate macrophage activation correlates with a protective IFN\u2010\u03b3 response and effective control of <jats:italic>C. muridarum<\/jats:italic>. These studies suggest that a quantitative or qualitative alteration in macrophages may play a key role in the development of <jats:italic>Chlamydia<\/jats:italic>\u2010associated diseases.<\/jats:p>","DOI":"10.1002\/eji.201545874","type":"journal-article","created":{"date-parts":[[2015,9,7]],"date-time":"2015-09-07T03:02:45Z","timestamp":1441594965000},"page":"3417-3430","source":"Crossref","is-referenced-by-count":9,"title":["Pulmonary <i>Chlamydia muridarum<\/i> challenge activates lung interstitial macrophages which correlate with IFN\u2010\u03b3 production and infection control in mice"],"prefix":"10.1002","volume":"45","author":[{"given":"Eric","family":"Gracey","sequence":"first","affiliation":[{"name":"Department of Immunology University of Toronto  Canada"},{"name":"Division of Genetics and Development Toronto Western Research Institute University Health Network  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuriy","family":"Baglaenko","sequence":"additional","affiliation":[{"name":"Department of Immunology University of Toronto  Canada"},{"name":"Division of Genetics and Development Toronto Western Research Institute University Health Network  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Prayitno","sequence":"additional","affiliation":[{"name":"Department of Immunology University of Toronto  Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nico","family":"Van Rooijen","sequence":"additional","affiliation":[{"name":"Vrije Universiteit Vrije Universiteit Medical Center Department of Molecular Cell Biology  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Akram","sequence":"additional","affiliation":[{"name":"Division of Genetics and Development Toronto Western Research Institute University Health Network  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aifeng","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Genetics and Development Toronto Western Research Institute University Health Network  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basil","family":"Chiu","sequence":"additional","affiliation":[{"name":"Division of Genetics and Development Toronto Western Research Institute University Health Network  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert D.","family":"Inman","sequence":"additional","affiliation":[{"name":"Department of Immunology University of Toronto  Canada"},{"name":"Division of Genetics and Development Toronto Western Research Institute University Health Network  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1096330"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002020"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2008.02130.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2008.02647.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp030542"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00012-13"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.femsre.2005.03.002"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.65.6.2145-2152.1997"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.162.5.2829"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199911)29:11<3782::AID-IMMU3782>3.0.CO;2-B"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/652397"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2478(02)00036-6"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364182"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.5.3197"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.12.5867-5875.1998"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.20.11143"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.5.3375"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.05.015"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.09.012"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3073"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004300050082"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0711336"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI39717"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1089\/jamp.2009.0797"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.3.2092"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir333"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2009.03157.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302269"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007308"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/170.2.464"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039214"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00963-08"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.5.2578-2586.2006"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60327-360-2_13"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(02)00361-8"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.6.3556-3561.2001"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.05535-11"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.9.4812"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21643"},{"key":"e_1_2_7_41_1","first-page":"e1488","article-title":"Isolation of mouse peritoneal cavity cells","volume":"35","author":"Ray A.","year":"2010","journal-title":"J. Visual. Experiments"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.19.5.3072"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006020"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1086\/515280"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201344359"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-11-124"},{"key":"e_1_2_7_47_1","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.4049\/jimmunol.157.7.3097","article-title":"Characterization of murine lung interstitial macrophages in comparison with alveolar macrophages in vitro","volume":"157","author":"Franke\u2010Ullmann G.","year":"1996","journal-title":"J. Immunol."},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3087"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevImmunol.v29.i4.10"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.64.11.4830-4833.1996"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00055-14"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(00)00015-0"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(98)80163-5"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03401798"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1224026"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2011.06273.x"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069421"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.201545874","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.201545874","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.201545874","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T21:22:53Z","timestamp":1696627373000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.201545874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,28]]},"references-count":56,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1002\/eji.201545874"],"URL":"https:\/\/doi.org\/10.1002\/eji.201545874","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,28]]}}}