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Under both steady\u2010state and inflammatory conditions, monocytes migrate into tissues and differentiate into macrophages. Macrophages in adipose and liver tissues play important roles in tissue homeostasis and pathogenesis of metabolic diseases. Here, we found that PILR\u03b1 controls monocyte mobility through regulating integrin signaling and inhibiting CD99\u2013CD99 binding. Moreover, we found that <jats:italic>Pilra<jats:sup>\u2212\/\u2212<\/jats:sup><\/jats:italic> mice developed obesity and hepatomegaly with fibrosis, and the numbers of macrophages in adipose and liver tissues are significantly increased in <jats:italic>Pilra<jats:sup>\u2212\/\u2212<\/jats:sup><\/jats:italic> mice. These data suggest that immune inhibitory receptor, PILR\u03b1, plays an important role in the prevention of obesity and liver fibrosis.<\/jats:p>","DOI":"10.1002\/eji.201545897","type":"journal-article","created":{"date-parts":[[2016,2,3]],"date-time":"2016-02-03T15:22:35Z","timestamp":1454512955000},"page":"1214-1223","source":"Crossref","is-referenced-by-count":35,"title":["Monocyte infiltration into obese and fibrilized tissues is regulated by PILR\u03b1"],"prefix":"10.1002","volume":"46","author":[{"given":"Masako","family":"Kohyama","sequence":"first","affiliation":[{"name":"Laboratory of Immunochemistry Immunology Frontier Research Center Osaka University  Suita Osaka Japan"},{"name":"Department of Immunochemistry Research Institute for Microbial Diseases Osaka University  Suita Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumiko","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Department of Immunochemistry Research Institute 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