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For this purpose, intestinal anaphylaxis was induced in BALB\/c mice with the food allergen hazelnut, in conjunction with different adjuvants (alum and Staphylococcal enterotoxin B SEB) and different administration routes (oral and intraperitoneal). In both models, allergy symptoms were observed, but the clinical severity was more pronounced in the hazelnut\u2010alum model than in the hazelnut\u2010SEB model. Accordingly, allergen\u2010specific immunoglobulin E (IgE) against hazelnut was detectable, and mast cell protease\u20101 in serum was increased after allergen provocation. Treatment with the proteasome inhibitor bortezomib reduced plasma cells and resulted in an abolishment of hazelnut allergen\u2010specific IgE, which was associated with amelioration of clinical symptoms as well as a significant decrease in both CD19<jats:sup>+<\/jats:sup> and follicular B lymphocytes. Our data demonstrate the importance of allergen\u2010specific IgE in food allergy and point to B cells as potential therapeutic targets for its treatment.<\/jats:p>","DOI":"10.1002\/eji.201545918","type":"journal-article","created":{"date-parts":[[2016,4,25]],"date-time":"2016-04-25T13:09:52Z","timestamp":1461589792000},"page":"1727-1736","source":"Crossref","is-referenced-by-count":11,"title":["Bortezomib treatment diminishes hazelnut\u2010induced intestinal anaphylaxis in mice"],"prefix":"10.1002","volume":"46","author":[{"given":"Kiran Kumar","family":"Mudnakudu Nagaraju","sequence":"first","affiliation":[{"name":"Department of Dermatology und Allergology Allergie\u2010Centrum\u2010Charit\u00e9, Charit\u00e9 \u2013 Universit\u00e4tsmedizin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magda","family":"Babina","sequence":"additional","affiliation":[{"name":"Department of Dermatology und Allergology Allergie\u2010Centrum\u2010Charit\u00e9, 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