{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:01:45Z","timestamp":1791842505753,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,12,9]],"date-time":"2015-12-09T00:00:00Z","timestamp":1449619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"DFG","award":["HO 4440\/1-1\/2"],"award-info":[{"award-number":["HO 4440\/1-1\/2"]}]},{"name":"DFG","award":["SFB\/TRR TR156"],"award-info":[{"award-number":["SFB\/TRR TR156"]}]},{"name":"DFG","award":["AW 1600\/8-1"],"award-info":[{"award-number":["AW 1600\/8-1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:p>NF\u2010\u03baB\u2010inducing kinase (NIK) is a key mediator of the noncanonical NF\u2010\u03baB signaling pathway, which is critical for normal B\u2010cell development and function. It is well established that the complete deletion of NIK in mice results in defective B cells and impaired secondary lymphoid organogenesis. To address the role of NIK deficiency specifically in B cells, we generated a new mouse strain for the conditional deletion of this kinase. Deletion of NIK during B\u2010cell development results in a drastic reduction of mature B cells from the transitional 2 stage on, while B\u20101 B cells are less affected. Moreover, deletion of NIK in the germinal centers decreases the numbers of germinal center B cells and impairs the ability of NIK\u2010deficient B cells to develop into class\u2010switched cells in vivo. This new mouse strain will be helpful for studying the role of NIK in different cell types of the body.<\/jats:p>","DOI":"10.1002\/eji.201546081","type":"journal-article","created":{"date-parts":[[2015,11,23]],"date-time":"2015-11-23T04:51:00Z","timestamp":1448254260000},"page":"732-741","source":"Crossref","is-referenced-by-count":44,"title":["NF\u2010\u03baB\u2010inducing kinase is essential for B\u2010cell maintenance in mice"],"prefix":"10.1002","volume":"46","author":[{"given":"Matthias","family":"Hahn","sequence":"first","affiliation":[{"name":"Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg University of Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Macht","sequence":"additional","affiliation":[{"name":"Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg University of Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ari","family":"Waisman","sequence":"additional","affiliation":[{"name":"Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg University of Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"H\u00f6velmeyer","sequence":"additional","affiliation":[{"name":"Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg University of Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2004.03.008"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri910"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2003.00049.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.01.020"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1062677"},{"key":"e_1_2_7_7_1","first-page":"1003","article-title":"Specific\u2010Inhibition of Relb\/P52 Transcriptional Activity by the C\u2010Terminal Domain of P100","volume":"10","author":"Dobrzanski P.","year":"1995","journal-title":"Oncogene"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600391"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M403286200"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.3123pe18"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-70630-6_11"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni842"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-70630-6_13"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00232-1"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/8780"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1058453"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.17.9302"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1061964"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(01)00598-X"},{"key":"e_1_2_7_20_1","doi-asserted-by":"crossref","first-page":"598","DOI":"10.4049\/jimmunol.157.2.598","article-title":"Bcmd governs recruitment of new B cells into the stable peripheral B cell pool in the A\/WySnJ mouse","volume":"157","author":"Lentz V. 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