{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:31:35Z","timestamp":1790181095946,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,7,18]],"date-time":"2016-07-18T00:00:00Z","timestamp":1468800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005677","name":"Jos\u00e9 Carreras Leuk\u00e4mie-Stiftung","doi-asserted-by":"publisher","award":["DJCLS R12\/29"],"award-info":[{"award-number":["DJCLS R12\/29"]}],"id":[{"id":"10.13039\/501100005677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB900\/B8"],"award-info":[{"award-number":["SFB900\/B8"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB900\/B7"],"award-info":[{"award-number":["SFB900\/B7"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB738\/A8"],"award-info":[{"award-number":["SFB738\/A8"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005624","name":"Medizinischen Hochschule Hannover","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005624","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:p>Upon antigen\u2010specific or allogeneic activation, T cells sharply increase their metabolic activity to cope with augmented needs for proliferation and effector functions. Therefore, enzymes involved in energy metabolism constitute attractive targets to modulate the activity of pathogenic effector T cells in the setting of graft\u2010versus\u2010host\u2010disease (GVHD). Here, we show that T cells deficient for acetyl\u2010CoA carboxylase 1 (TACC1) are dramatically less pathogenic than wild\u2010type (WT) T cells in a lethal C57BL\/6 into BALB\/c model of acute GVHD and permitted sustained survival of recipient mice. In line with this clinical observation, higher frequencies of GVHD\u2010suppressing Foxp3<jats:sup>+<\/jats:sup> regulatory T (Treg) cells were detected in the colon of TACC T\u2010cell recipients. In vitro, T\u2010cell stimulation with allogeneic DCs induced higher proportions of Treg cells but also led to diminished proliferation of TACC1 T cells compared to WT T cells. Furthermore, TACC1 T cells activated by allogeneic DCs showed impaired glycolysis and lipid synthesis. Thus, targeting de novo fatty acid synthesis via acetyl\u2010CoA carboxylase inhibition may be a promising new strategy to prevent GVHD.<\/jats:p>","DOI":"10.1002\/eji.201546152","type":"journal-article","created":{"date-parts":[[2016,6,24]],"date-time":"2016-06-24T09:17:01Z","timestamp":1466759821000},"page":"2233-2238","source":"Crossref","is-referenced-by-count":45,"title":["Disruption of de novo fatty acid synthesis via acetyl\u2010CoA carboxylase 1 inhibition prevents acute graft\u2010versus\u2010host disease"],"prefix":"10.1002","volume":"46","author":[{"given":"Solaiman","family":"Raha","sequence":"first","affiliation":[{"name":"Institute of Immunology Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda","family":"Raud","sequence":"additional","affiliation":[{"name":"Institute of Infection Immunology, Centre for Experimental and Clinical Infection Research TWINCORE  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Oberd\u00f6rfer","sequence":"additional","affiliation":[{"name":"Institute of Immunology Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla N.","family":"Castro","sequence":"additional","affiliation":[{"name":"Institute of Infection Immunology, Centre for Experimental and Clinical Infection Research TWINCORE  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Schreder","sequence":"additional","affiliation":[{"name":"Institute of Immunology Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Freitag","sequence":"additional","affiliation":[{"name":"Institute of Infection Immunology, Centre for Experimental and Clinical Infection Research TWINCORE  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Longerich","sequence":"additional","affiliation":[{"name":"Institute of Pathology Universit\u00e4tsklinikum Aachen  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Lochner","sequence":"additional","affiliation":[{"name":"Institute of Infection Immunology, Centre for Experimental and Clinical Infection Research TWINCORE  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Sparwasser","sequence":"additional","affiliation":[{"name":"Institute of Infection Immunology, Centre for Experimental and Clinical Infection Research TWINCORE  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Berod","sequence":"additional","affiliation":[{"name":"Institute of Infection Immunology, Centre for Experimental and Clinical Infection Research TWINCORE  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Koenecke","sequence":"additional","affiliation":[{"name":"Institute of Immunology Hannover Medical School  Hannover Germany"},{"name":"Department of Hematology, Hemostasis, Oncology and Stem\u2010Cell Transplantation Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Immo","family":"Prinz","sequence":"additional","affiliation":[{"name":"Institute of Immunology Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20151159"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2014.12.005"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00323-0"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2005"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1160809"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003613"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.07.033"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20110278"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3704"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200939432"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.10.5991"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-08-044529"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-08-2827"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302985"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-04-495515"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2015.07.023"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00227-8"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0603115103"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200413"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001652"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.8.3230.bloodjournal8883230"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.201546152","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.201546152","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.201546152","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/eji.201546152","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.201546152","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T05:07:57Z","timestamp":1694149677000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.201546152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,18]]},"references-count":21,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1002\/eji.201546152"],"URL":"https:\/\/doi.org\/10.1002\/eji.201546152","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,18]]}}}